KEGG   ENZYME: 3.4.21.12Help
Entry
EC 3.4.21.12                Enzyme                                 

Name
alpha-lytic endopeptidase;
myxobacter alpha-lytic proteinase;
alpha-lytic proteinase;
alpha-lytic protease;
Mycobacterium sorangium alpha-lytic proteinase;
Myxobacter 495 alpha-lytic proteinase;
alpha-lytic proteinase;
Myxobacter alpha-lytic proteinase;
Mycobacterium sorangium alpha-lytic proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Ala!, Val! in bacterial cell walls, elastin and other proteins
Comment
From the myxobacterium Lysobacter enzymogenes. In peptidase family S1 (trypsin family)
History
EC 3.4.21.12 created 1972
Reference
1  [PMID:5482494]
  Authors
Olson MO, Nagabhushan N, Dzwiniel M, Smillie LB, Whitaker DR.
  Title
Priaary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases.
  Journal
Nature. 228 (1970) 438-42.
Reference
2
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
3  [PMID:3053694]
  Authors
Epstein DM, Wensink PC.
  Title
The alpha-lytic protease gene of Lysobacter enzymogenes. The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes.
  Journal
J. Biol. Chem. 263 (1988) 16586-90.
  Sequence
[up:P00778]
Reference
4  [PMID:2611204]
  Authors
Bone R, Frank D, Kettner CA, Agard DA.
  Title
Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
  Journal
Biochemistry. 28 (1989) 7600-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37288-76-9

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