KEGG   ENZYME: 3.4.21.21Help
Entry
EC 3.4.21.21                Enzyme                                 
Name
coagulation factor VIIa;
blood-coagulation factor VIIa;
activated blood coagulation factor VII
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family)
Orthology
K01320  
coagulation factor VII
Genes
HSA: 
2155(F7)
PTR: 
744785(F7)
PPS: 
GGO: 
PON: 
MCC: 
721933(F7)
MMU: 
14068(F7)
RNO: 
260320(F7)
CFA: 
607661(F7)
AML: 
FCA: 
101090581(F7)
BTA: 
617960(F7)
SSC: 
733661(F7)
ECB: 
100067072
MDO: 
100022420
SHR: 
100921248(F7)
GGA: 
395086(F7)
TGU: 
100223776(F7)
ACS: 
100555133
XLA: 
444394(f7)
XTR: 
780280(f7)
DRE: 
100038778 114423(f7)
TRU: 
445941 446072
OLA: 
101154762 101155013
 » show all
Taxonomy
Reference
1  [PMID:4510277]
  Authors
Nemerson Y, Esnouf MP.
  Title
Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 310-4.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
3  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu. Rev. Biochem. 49 (1980) 765-811.
Reference
4
  Authors
Broze, G.J., Jr. and Majerus, P.W.
  Title
Human factor VII.
  Journal
Methods Enzymol. 80 (1981) 228-237.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65312-43-8
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