KEGG   ENZYME: 3.4.21.21Help
Entry
EC 3.4.21.21                Enzyme                                 

Name
coagulation factor VIIa;
blood-coagulation factor VIIa;
activated blood coagulation factor VII
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family)
History
EC 3.4.21.21 created 1978
Orthology
K01320  
coagulation factor VII
Genes
HSA: 
2155(F7)
PTR: 
744785(F7)
PPS: 
GGO: 
PON: 
MCC: 
721933(F7)
MCF: 
MMU: 
14068(F7)
RNO: 
260320(F7)
CGE: 
HGL: 
TUP: 
CFA: 
607661(F7)
AML: 
FCA: 
PTG: 
BTA: 
617960(F7)
BOM: 
CHX: 
OAS: 
SSC: 
733661(F7)
CFR: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
GGA: 
395086(F7)
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
XLA: 
444394(f7)
XTR: 
780280(f7)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:4510277]
  Authors
Nemerson Y, Esnouf MP.
  Title
Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 310-4.
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
3  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu. Rev. Biochem. 49 (1980) 765-811.
Reference
4
  Authors
Broze, G.J., Jr. and Majerus, P.W.
  Title
Human factor VII.
  Journal
Methods Enzymol. 80 (1981) 228-237.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65312-43-8

DBGET integrated database retrieval system