KEGG   ENZYME: 3.4.21.22Help
Entry
EC 3.4.21.22                Enzyme                                 
Name
coagulation factor IXa;
activated Christmas factor;
blood-coagulation factor IXa;
activated blood-coagulation factor IX;
autoprothrombin II;
blood platelet cofactor II;
activated blood coagulation factor XI
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)
Orthology
K01321  
coagulation factor IX (Christmas factor)
Genes
HSA: 
2158(F9)
PTR: 
465887(F9)
PPS: 
PON: 
MCC: 
695578(F9)
MMU: 
14071(F9)
RNO: 
24946(F9)
CFA: 
404015(F9)
AML: 
FCA: 
493973(F9)
BTA: 
280688(F9)
SSC: 
397518(F9)
ECB: 
100054449(F9)
MDO: 
100012394(F9)
SHR: 
100921381(F9)
OAA: 
100082935(F9)
GGA: 
374258(F9)
MGP: 
100551218
TGU: 
100225886(F9)
ACS: 
100563567
XLA: 
100049721(f9)
XTR: 
496659(f9)
DRE: 
678552(f9b)
TRU: 
101068927 445943(f9)
 » show all
Taxonomy
Reference
1  [PMID:1012029]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor IX (Christmas factor).
  Journal
Methods. Enzymol. 45 (1976) 74-83.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
3  [PMID:6412750]
  Authors
Link RP, Castellino FJ.
  Title
Kinetic comparison of bovine blood coagulation factors IXa alpha and IXa beta toward bovine factor X.
  Journal
Biochemistry. 22 (1983) 4033-41.
  Organism
Bos taurus [GN:bta]
Reference
4  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37316-87-3
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