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Entry
EC 3.4.21.27                Enzyme                                 

Name
coagulation factor XIa;
blood-coagulation factor XIa;
activated blood-coagulation factor XI;
activated plasma thromboplastin antecedent
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ala and Arg!Val bonds in factor IX to form factor IXa
Comment
In peptidase family S1 (trypsin family), and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa
History
EC 3.4.21.27 created 1978
Orthology
K01323  
coagulation factor XI
Genes
HSA: 
2160(F11)
PTR: 
461643(F11)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
702117(F11)
MCF: 
CJC: 
MMU: 
109821(F11)
RNO: 
290757(F11)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
475623(F11)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
407998(F11)
BOM: 
PHD: 
CHX: 
OAS: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
TGU: 
TRU: 
MZE: 
XMA: 
 » show all
Taxonomy
Reference
1
  Authors
Kurachi, K. and Davie, E.W.
  Title
Human factor XI (plasma thromboplastin antecedent).
  Journal
Methods Enzymol. 80 (1981) 211-220.
Reference
2  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
Reference
3  [PMID:3636155]
  Authors
Fujikawa K, Chung DW, Hendrickson LE, Davie EW.
  Title
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.
  Journal
Biochemistry. 25 (1986) 2417-24.
  Sequence
[hsa:2160]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37203-61-5

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