KEGG   ENZYME: 3.4.21.35Help
Entry
EC 3.4.21.35                Enzyme                                 

Name
tissue kallikrein;
glandular kallikrein;
pancreatic kallikrein;
submandibular kallikrein;
submaxillary kallikrein;
kidney kallikrein;
urinary kallikrein;
kallikrein;
salivary kallikrein;
kininogenin;
kininogenase;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
depot-padutin;
urokallikrein;
dilminal D;
onokrein P
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of Arg! bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met! or Leu!. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg! bonds [5]
Comment
Formed from tissue prokallikrein by activation with trypsin. In peptidase family S1 (trypsin family). A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse gamma-renin (EC 3.4.21.54), submandibular proteinase A [2,15], epidermal growth-factor-binding protein, nerve growth factor gamma-subunit, rat tonin [3,4,9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (gamma-seminoprotein, [6])
History
EC 3.4.21.35 created 1965 as EC 3.4.4.21, transferred 1972 to 3.4.21.8, part transferred 1981 to EC 3.4.21.35
Orthology
K01325  
tissue kallikrein
Genes
HSA: 
3816(KLK1) 3817(KLK2)
PTR: 
748637(KLK2)
PPS: 
100967412(KLK2) 100995152(KLK1)
GGO: 
101144843(KLK1)
PON: 
NLE: 
MCC: 
719436(KLK2)
MCF: 
102135781(KLK1) 102139474(KLK2)
CJC: 
100402463(KLK1)
MMU: 
13646(Klk1b22) 13648(Klk1b9) 16612(Klk1) 16613(Klk1b11) 16616(Klk1b21) 16617(Klk1b24) 16618(Klk1b26) 16622(Klk1b5) 16623(Klk1b1) 16624(Klk1b8) 18050(Klk1b3)
RNO: 
24523(Klk1c7) 24594(Klk1) 24841(Klk1c2) 292855(Klk1c12) 292866(Klk1c8)
CGE: 
100754155(Klk1)
NGI: 
HGL: 
101719001(Klk1)
OCU: 
TUP: 
102489025(KLK1)
CFA: 
403942(KLK1) 403967(KLK2)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
493738(KLK1)
BOM: 
102283027(KLK1)
PHD: 
102344140(KLK1)
CHX: 
102177186(KLK1)
OAS: 
100048991(KLK1)
SSC: 
431673(KLK1)
CFR: 
102515972(KLK1)
BACU: 
103007165(KLK1)
LVE: 
103081797(KLK1)
ECB: 
100034023(KLK1E2) 100147008(KLK1E1)
MYB: 
102251175(KLK1)
MYD: 
102765308(KLK1)
PALE: 
AHA: 
 » show all
Taxonomy
Reference
1  [PMID:7043199]
  Authors
Fiedler F, Fink E, Tschesche H, Fritz H.
  Title
Porcine glandular kallikreins.
  Journal
Methods. Enzymol. 80 Pt C (1981) 493-532.
  Sequence
[ssc:431673]
Reference
2  [PMID:6295764]
  Authors
Anundi H, Ronne H, Peterson PA, Rask L.
  Title
Partial amino-acid sequence of the epidermal growth-factor-binding protein.
  Journal
Eur. J. Biochem. 129 (1982) 365-71.
Reference
3  [PMID:6295383]
  Authors
Pesquero JL, Boschcov P, Oliveira MC, Paiva AC.
  Title
Effect of substrate size on tonin activity.
  Journal
Biochem. Biophys. Res. Commun. 108 (1982) 1441-6.
Reference
4  [PMID:6043136]
  Authors
Schack P.
  Title
Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme.
  Journal
C. R. Trav. Lab. Carlsberg. 36 (1967) 67-83.
Reference
5  [PMID:3844939]
  Authors
Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S.
  Title
Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins.
  Journal
Biochem. Biophys. Res. Commun. 127 (1985) 289-95.
Reference
6  [PMID:3691800]
  Authors
Akiyama K, Nakamura T, Iwanaga S, Hara M.
  Title
The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein.
  Journal
FEBS. Lett. 225 (1987) 168-72.
Reference
7  [PMID:3036794]
  Authors
Evans BA, Drinkwater CC, Richards RI.
  Title
Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.
  Journal
J. Biol. Chem. 262 (1987) 8027-34.
  Sequence
[mmu:16623]
Reference
8  [PMID:3643848]
  Authors
Fiedler F.
  Title
Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin.
  Journal
Eur. J. Biochem. 163 (1987) 303-12.
Reference
9  [PMID:2821276]
  Authors
Fujinaga M, James MN.
  Title
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
  Journal
J. Mol. Biol. 195 (1987) 373-96.
  Sequence
[rno:24841]
Reference
10 [PMID:3844939]
  Authors
Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S.
  Title
Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins.
  Journal
Biochem. Biophys. Res. Commun. 127 (1985) 289-95.
Reference
11 [PMID:3237072]
  Authors
Bailey GS.
  Title
Rat pancreas kallikrein.
  Journal
Methods. Enzymol. 163 (1988) 115-28.
Reference
12 [PMID:2611215]
  Authors
Blaber M, Isackson PJ, Marsters JC Jr, Burnier JP, Bradshaw RA.
  Title
Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland.
  Journal
Biochemistry. 28 (1989) 7813-9.
Reference
13 [PMID:3070295]
  Authors
Chao J, Chao L.
  Title
Rat urinary kallikrein.
  Journal
Methods. Enzymol. 163 (1988) 128-43.
Reference
14 [PMID:2975076]
  Authors
Zakrevskaia SF.
  Title
[Effectiveness of outpatient dental care for the schoolchildren of Arkhangelsk]
  Journal
Stomatologiia. (Mosk). 67 (1988) 62-3.
Reference
15 [PMID:2523317]
  Authors
Bertrand R, Derancourt J, Kassab R.
  Title
Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C.
  Journal
FEBS. Lett. 246 (1989) 171-6.
Reference
16 [PMID:2708383]
  Authors
Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ.
  Title
Organization and expression of the rat kallikrein gene family.
  Journal
J. Biol. Chem. 264 (1989) 7653-62.
  Sequence
[rno:24594 24841]
Reference
17 [PMID:2194829]
  Authors
Elmoujahed A, Gutman N, Brillard M, Gauthier F.
  Title
Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland.
  Journal
FEBS. Lett. 265 (1990) 137-40.
Reference
18 [PMID:2303430]
  Authors
Xiong W, Chen LM, Chao J.
  Title
Purification and characterization of a kallikrein-like T-kininogenase.
  Journal
J. Biol. Chem. 265 (1990) 2822-7.
  Sequence
[rno:292858]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
389069-73-2

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