KEGG   ENZYME: 3.4.21.37Help
Entry
EC 3.4.21.37                Enzyme                                 

Name
leukocyte elastase;
lysosomal elastase;
neutrophil elastase;
polymorphonuclear leukocyte elastase;
elastase;
elaszym;
serine elastase;
lysosomal elastase;
granulocyte elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage Val! > Ala!
Comment
Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.37 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01327  
leukocyte elastase
Genes
HSA: 
1991(ELANE)
PTR: 
749897(ELANE)
PPS: 
GGO: 
101136126(ELANE)
PON: 
100452808(ELANE)
MCF: 
102135637(ELANE)
MMU: 
50701(Elane)
RNO: 
299606(Elane)
CGE: 
100752732(Elane)
HGL: 
TUP: 
102488298(ELANE)
CFA: 
442980(ELANE)
FCA: 
100301482(ELANE)
PTG: 
102951727(ELANE)
BTA: 
100126050(ELANE)
BOM: 
102274925(ELANE)
PHD: 
102322848(ELANE)
CHX: 
102173292(ELANE)
OAS: 
101110841(ELANE)
SSC: 
100522182(ELANE)
CFR: 
102507529(ELANE)
BACU: 
103003856(ELANE)
LVE: 
103074519(ELANE)
MYD: 
102756029(ELANE)
PALE: 
102888696(ELANE)
MDO: 
100030465(ELANE)
SHR: 
100932763(ELANE)
OAA: 
XTR: 
448597(prtn3)
 » show all
Taxonomy
Reference
1  [PMID:7043201]
  Authors
Barrett AJ.
  Title
Leukocyte elastase.
  Journal
Methods. Enzymol. 80 Pt C (1981) 581-8.
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry. 23 (1984) 2995-3002.
  Organism
Homo sapiens, Rattus norvegicus, Bos taurus, Staphylococcus aureus
Reference
3  [PMID:3646070]
  Authors
Stein RL, Strimpler AM, Hori H, Powers JC.
  Title
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
  Journal
Biochemistry. 26 (1987) 1301-5.
  Organism
Homo sapiens
Reference
4  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry. 28 (1989) 1951-63.
  Organism
Homo sapiens, Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9004-06-2

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