KEGG   ENZYME: 3.4.21.38Help
Entry
EC 3.4.21.38                Enzyme                                 
Name
coagulation factor XIIa;
Hageman factor (activated);
blood-coagulation factor XIIf;
activated beta blood-coagulation factor XII;
prealbumin activator;
Hageman factor beta-fragment;
Hageman factor fragment HFf;
blood-coagulation factor XIIabeta;
prekallikrein activator;
kallikreinogen activator
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Comment
Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family)
Orthology
K01328  
coagulation factor XII (Hageman factor)
Genes
HSA: 
2161(F12)
PTR: 
462304(F12)
PPS: 
GGO: 
PON: 
MCC: 
699875(F12)
MMU: 
58992(F12)
RNO: 
306761(F12)
CFA: 
489090(F12)
AML: 
FCA: 
100313488(F12)
BTA: 
280789(F12)
SSC: 
397474(F12)
ECB: 
100068589(F12)
MDO: 
100031953
SHR: 
100922168(F12)
OAA: 
100087798
ACS: 
100555717
XTR: 
100493769
 » show all
Taxonomy
Reference
1  [PMID:6918768]
  Authors
Fujikawa K, Davie EW.
  Title
Human factor XII (Hageman factor).
  Journal
Methods. Enzymol. 80 Pt C (1981) 198-211.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta]
Reference
3  [PMID:3011063]
  Authors
Que BG, Davie EW.
  Title
Characterization of a cDNA coding for human factor XII (Hageman factor).
  Journal
Biochemistry. 25 (1986) 1525-8.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:3237089]
  Authors
Fujikawa K.
  Title
Bovine Hageman factor and its fragments.
  Journal
Methods. Enzymol. 163 (1988) 54-68.
  Organism
Bos taurus [GN:bta]
Reference
5  [PMID:3237092]
  Authors
Silverberg M, Kaplan AP.
  Title
Human Hageman factor and its fragments.
  Journal
Methods. Enzymol. 163 (1988) 68-80.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
75216-42-1
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