KEGG   ENZYME: 3.4.21.39Help
Entry
EC 3.4.21.39                Enzyme                                 

Name
chymase;
mast cell protease I;
skeletal muscle protease;
skin chymotryptic proteinase;
mast cell serine proteinase, chymase;
skeletal muscle (SK) protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Phe! > Tyr! > Trp! > Leu!
Comment
In mast cell granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.39 created 1981
Orthology
K01329  
chymase
Genes
HSA: 
1215(CMA1)
PTR: 
745533(CMA1)
PPS: 
100986161(CMA1)
GGO: 
101131787(CMA1)
PON: 
100432060(CMA1)
NLE: 
100590719(CMA1)
MCC: 
716395(CMA1)
MCF: 
102128612(CMA1)
CJC: 
100388845(CMA1)
MMU: 
17228(Cma1)
RNO: 
25627(Cma1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
490628(CMA1)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
BACU: 
103010490(CMA1)
LVE: 
103078045(CMA1)
ECB: 
MYB: 
MYD: 
PALE: 
102891376(CMA1)
MDO: 
100025555(CMA1)
SHR: 
 » show all
Taxonomy
Reference
1  [PMID:7043202]
  Authors
Woodbury RG, Everitt MT, Neurath H.
  Title
Mast cell proteases.
  Journal
Methods. Enzymol. 80 Pt C (1981) 588-609.
Reference
2  [PMID:3893542]
  Authors
Powers JC, Tanaka T, Harper JW, Minematsu Y, Barker L, Lincoln D, Crumley KV, Fraki JE, Schechter NM, Lazarus GG, et al.
  Title
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.
  Journal
Biochemistry. 24 (1985) 2048-58.
Reference
3  [PMID:2425663]
  Authors
Johnson LA, Moon KE, Eisenberg M.
  Title
Purification to homogeneity of the human skin chymotryptic proteinase "chymase".
  Journal
Anal. Biochem. 155 (1986) 358-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97501-92-3

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