KEGG   ENZYME: 3.4.21.41Help
Entry
EC 3.4.21.41                Enzyme                                 
Name
complement subcomponent C_overbar_1r_;
activated complement C1r;
C_overbar_1r_ esterase;
activated complement C1r
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Comment
Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
Orthology
K01330  
complement component 1, r subcomponent
Genes
HSA: 
715(C1R)
PTR: 
466939(C1R)
PPS: 
GGO: 
PON: 
MCC: 
722133(C1R)
MMU: 
50909(C1ra)
RNO: 
312705(C1r)
CFA: 
477707(C1R)
AML: 
FCA: 
101088940(C1R)
BTA: 
507706 511581(C1R)
SSC: 
445464(C1R)
ECB: 
100060297(C1R)
MDO: 
100016799
SHR: 
100925028
OAA: 
100090998
GGA: 
418295(C1R)
MGP: 
100549554(C1R)
TGU: 
100224962(C1R)
ACS: 
100558220
XLA: 
735208
XTR: 
100498646
TRU: 
101072695
OLA: 
101173495
 » show all
Taxonomy
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods. Enzymol. 80 Pt C (1981) 26-42.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3021205]
  Authors
Leytus SP, Kurachi K, Sakariassen KS, Davie EW.
  Title
Nucleotide sequence of the cDNA coding for human complement C1r.
  Journal
Biochemistry. 25 (1986) 4855-63.
  Organism
Homo sapiens [GN:hsa]
  Sequence
HSA: 715
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu. Rev. Biochem. 57 (1988) 321-47.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80295-69-8
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