KEGG   ENZYME: 3.4.21.41Help
Entry
EC 3.4.21.41                Enzyme                                 

Name
complement subcomponent C_overbar_1r_;
activated complement C1r;
C_overbar_1r_ esterase;
activated complement C1r
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Comment
Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
History
EC 3.4.21.41 created 1981
Orthology
K01330  
complement component 1, r subcomponent
Genes
HSA: 
715(C1R)
PTR: 
466939(C1R)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
722133(C1R)
MCF: 
CJC: 
MMU: 
50909(C1ra)
RNO: 
312705(C1r)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
477707(C1R)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
PHD: 
CHX: 
OAS: 
SSC: 
445464(C1R)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
418295(C1R)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
XTR: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods. Enzymol. 80 Pt C (1981) 26-42.
Reference
2  [PMID:3021205]
  Authors
Leytus SP, Kurachi K, Sakariassen KS, Davie EW.
  Title
Nucleotide sequence of the cDNA coding for human complement C1r.
  Journal
Biochemistry. 25 (1986) 4855-63.
  Sequence
[hsa:715]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu. Rev. Biochem. 57 (1988) 321-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80295-69-8

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