KEGG   ENZYME: 3.4.21.45Help
Entry
EC 3.4.21.45                Enzyme                                 

Name
complement factor I;
complement component C3b inactivator;
C3b inactivator;
C3b/C4b inactivator;
C3bINA;
complement C3b/C4b inactivator;
complement C4b inactivator;
conglutinogen-activating factor C;
complement C3b inactivator;
factor I;
complement C4bi
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
Comment
Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family)
History
EC 3.4.21.45 created 1981
Orthology
K01333  
complement factor I
Genes
HSA: 
3426(CFI)
PTR: 
471271(CFI)
PPS: 
GGO: 
PON: 
MCC: 
MCF: 
MMU: 
12630(Cfi)
RNO: 
79126(Cfi)
CGE: 
HGL: 
TUP: 
CFA: 
478515(CFI)
AML: 
FCA: 
PTG: 
BTA: 
513197(CFI)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
428773(CFI)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379108(cfi-a)
XTR: 
613100(cfi)
DRE: 
557557(cfi)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:7391570]
  Authors
Nagasawa S, Ichihara C, Stroud RM.
  Title
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator.
  Journal
J. Immunol. 125 (1980) 578-82.
Reference
2  [PMID:6210825]
  Authors
Crossley LG.
  Title
C3b inactivator and beta 1H.
  Journal
Methods. Enzymol. 80 Pt C (1981) 112-24.
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu. Rev. Biochem. 57 (1988) 321-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80295-66-5

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