KEGG   ENZYME: 3.4.21.59Help
Entry
EC 3.4.21.59                Enzyme                                 

Name
tryptase;
mast cell tryptase;
mast cell protease II;
skin tryptase;
lung tryptase;
pituitary tryptase;
mast cell neutral proteinase;
mast cell tryptase;
mast cell neutral proteinase;
mast cell serine proteinase II;
mast cell proteinase II;
mast cell serine proteinase tryptase;
rat mast cell protease II;
tryptase M
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!, but with more restricted specificity than trypsin
Comment
Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin
History
EC 3.4.21.59 created 1992
Orthology
K01340  
tryptase
Genes
HSA: 
23430(TPSD1) 64499(TPSB2) 7177(TPSAB1)
PTR: 
454333(TPSB2) 468084
PPS: 
GGO: 
PON: 
MCC: 
699599(TPSB2)
MCF: 
102139613(TPSB2) 102140229(TPSAB1)
MMU: 
100503895(Tpsab1) 17229(Tpsb2)
RNO: 
29268(Tpsb2) 54271(Tpsab1)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
BTA: 
281545(TPSB1) 786948
BOM: 
PHD: 
CHX: 
SSC: 
397389(MCT7)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
102258623(TPSB2) 102258917(TPSAB1)
MYD: 
PALE: 
102890577(TPSAB1)
MDO: 
SHR: 
OAA: 
BBA: 
BBAC: 
 » show all
Taxonomy
Reference
1  [PMID:6358206]
  Authors
Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC.
  Title
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
  Journal
J. Biol. Chem. 258 (1983) 13552-7.
  Organism
Homo sapiens, Bos taurus
Reference
2  [PMID:3890754]
  Authors
Kido H, Fukusen N, Katunuma N.
  Title
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions.
  Journal
Arch. Biochem. Biophys. 239 (1985) 436-43.
  Organism
Rattus norvegicus
Reference
3  [PMID:3543004]
  Authors
Cromlish JA, Seidah NG, Marcinkiewicz M, Hamelin J, Johnson DA, Chretien M.
  Title
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
  Journal
J. Biol. Chem. 262 (1987) 1363-73.
  Organism
Homo sapiens
  Sequence
[hsa:7177]
Reference
4  [PMID:3140898]
  Authors
Harvima IT, Schechter NM, Harvima RJ, Fraki JE.
  Title
Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.
  Journal
Biochim. Biophys. Acta. 957 (1988) 71-80.
  Organism
Homo sapiens
Reference
5  [PMID:2187193]
  Authors
Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH.
  Title
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 3811-5.
  Organism
Homo sapiens
  Sequence
[hsa:7177 64499]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97501-93-4

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