KEGG   ENZYME: 3.4.21.64Help
Entry
EC 3.4.21.64                Enzyme                                 

Name
peptidase K;
Tritirachium alkaline proteinase;
Tritirachium album serine proteinase;
proteinase K;
Tritirachium album proteinase K;
endopeptidase K
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyses peptide amides
Comment
From the mold Tritirachium album Limber. A peptidase of family S8 (subtilisin family) containing two disulfide bridges and one free Cys near the active site His. Formerly included in EC 3.4.21.14
History
EC 3.4.21.64 created 1992 (EC 3.4.21.14 created 1961 as EC 3.4.4.16, transferred 1972 to EC 3.4.21.14, modified 1986, part incorporated 1992)
Reference
1  [PMID:4373242]
  Authors
Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H.
  Title
Proteinase K from Tritirachium album Limber.
  Journal
Eur. J. Biochem. 47 (1974) 91-7.
  Organism
Tritirachium album
Reference
2
  Authors
Morihara, K. and Tsuzuki, H.
  Title
Specificity of proteinase K from Tritirachium album Limber for synthetic peptides.
  Journal
Agric. Biol. Chem. 39 (1975) 1489-1492.
Reference
3  [PMID:943367]
  Authors
Kraus E, Kiltz HH, Femfert UF.
  Title
The specificity of proteinase K against oxidized insulin B chain.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 357 (1976) 233-7.
  Organism
Tritirachium album
Reference
4
  Authors
Jany, K.-D., Lederer, G. and Mayer, B.
  Title
Amino acid sequence of proteinase K from the mold Tritirachium album Limber.
  Journal
FEBS Lett. 199 (1986) 139-144.
Reference
5  [PMID:2184432]
  Authors
Betzel C, Teplyakov AV, Harutyunyan EH, Saenger W, Wilson KS.
  Title
Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes.
  Journal
Protein. Eng. 3 (1990) 161-72.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39450-01-6

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