KEGG   ENZYME: 3.4.21.69Help
Entry
EC 3.4.21.69                Enzyme                                 

Name
protein C (activated);
blood-coagulation factor XIVa;
activated blood coagulation factor XIV;
activated protein C;
autoprothrombin II-A;
protein Ca;
APC;
GSAPC
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Degradation of blood coagulation factors Va and VIIIa
Comment
A peptidase of family S1 (trypsin family), one of the gamma-carboxyglutamic acid-containing coagulation factors. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms
History
EC 3.4.21.69 created 1992
Orthology
K01344  
protein C (activated)
Genes
HSA: 
5624(PROC)
PTR: 
459593(PROC)
PPS: 
100972665(PROC)
GGO: 
101151624(PROC)
PON: 
100448857(PROC)
MCC: 
699077(PROC)
MCF: 
102136210(PROC)
MMU: 
19123(Proc)
RNO: 
25268(Proc)
CGE: 
100772264(Proc)
HGL: 
101696423(Proc)
TUP: 
102484495(PROC)
CFA: 
476104(PROC)
AML: 
FCA: 
101096161(PROC)
PTG: 
102964953(PROC)
BTA: 
281428(PROC)
BOM: 
102273407(PROC)
PHD: 
102339034(PROC)
CHX: 
102178773(PROC)
SSC: 
396954(PROC)
CFR: 
102512086(PROC)
BACU: 
103016343(PROC)
LVE: 
103082864(PROC)
ECB: 
100051306(PROC)
MYB: 
102252251(PROC)
MYD: 
102753299(PROC)
PALE: 
102880670(PROC)
MDO: 
100026692(PROC)
SHR: 
100916453(PROC)
OAA: 
100089432(PROC)
GGA: 
395085(PROC)
MGP: 
TGU: 
100231143(PROC)
FAB: 
101811071(PROC)
PHI: 
102100991(PROC)
APLA: 
101796776(PROC)
FPG: 
101913876(PROC)
FCH: 
102047415(PROC)
CLV: 
102097119(PROC)
ASN: 
102372857(PROC)
AMJ: 
102571855(PROC)
PSS: 
102461421(PROC)
CMY: 
102934451(PROC)
ACS: 
PBI: 
103049304(PROC)
XLA: 
380116(proc)
XTR: 
548476(proc)
DRE: 
393327(proca)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103186701(proc)
 » show all
Taxonomy
Reference
1  [PMID:3029867]
  Authors
Esmon CT.
  Title
The regulation of natural anticoagulant pathways.
  Journal
Science. 235 (1987) 1348-52.
  Organism
Homo sapiens
Reference
2  [PMID:2538457]
  Authors
Esmon CT
  Title
The roles of protein C and thrombomodulin in the regulation of blood coagulation.
  Journal
J. Biol. Chem. 264 (1989) 4743-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
42617-41-4

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