KEGG   ENZYME: 3.4.21.7Help
Entry
EC 3.4.21.7                 Enzyme                                 

Name
plasmin;
fibrinase;
fibrinolysin;
actase;
serum tryptase;
thrombolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Lys! > Arg!; higher selectivity than trypsin. Converts fibrin into soluble products
Comment
Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.7 created 1961 as EC 3.4.4.14, transferred 1972 to EC 3.4.21.7
Orthology
K01315  
plasminogen
Genes
HSA: 
5340(PLG)
PTR: 
463117(PLG)
PPS: 
GGO: 
PON: 
MCC: 
703891(PLG)
MCF: 
MMU: 
18815(Plg)
RNO: 
85253(Plg)
CGE: 
HGL: 
TUP: 
CFA: 
403602(PLG)
AML: 
FCA: 
PTG: 
BTA: 
280897(PLG)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
733660(PLG)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
421580(PLG)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
DRE: 
322691(plg)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
API: 
TSP: 
TAD: 
MIS: 
TPS: 
EHX: 
BBA: 
Bd0994(splA)
BBAT: 
Bdt_0940(splA)
BBAC: 
 » show all
Taxonomy
Reference
1  [PMID:138065]
  Authors
Castellino FJ, Sodetz JM.
  Title
Rabbit plasminogen and plasmin isozymes.
  Journal
Methods. Enzymol. 45 (1976) 273-86.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:6210827]
  Authors
Castellino FJ, Powell JR.
  Title
Human plasminogen.
  Journal
Methods. Enzymol. 80 Pt C (1981) 365-78.
  Organism
Homo sapiens
Reference
3  [PMID:6210828]
  Authors
Robbins KC, Summaria L, Wohl RC.
  Title
Human plasmin.
  Journal
Methods. Enzymol. 80 Pt C (1981) 379-87.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-90-5

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