KEGG   ENZYME: 3.4.21.70Help
Entry
EC 3.4.21.70                Enzyme                                 

Name
pancreatic endopeptidase E;
cholesterol-binding proteinase;
proteinase E;
cholesterol-binding serine proteinase;
pancreatic protease E;
pancreatic proteinase E;
cholesterol-binding pancreatic proteinase;
CBPP;
pancreas E proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Ala!. Does not hydrolyse elastin
Comment
A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol
History
EC 3.4.21.70 created 1992
Orthology
K01345  
pancreatic endopeptidase E
Genes
HSA: 
10136(CELA3A) 23436(CELA3B)
PTR: 
456491(CELA3B) 749169(CELA3A)
PPS: 
100969372(CELA3A)
GGO: 
101137143(CELA3B)
PON: 
100439784(CELA3B)
MCC: 
574236(CELA3B)
MCF: 
102144846(CELA3B)
MMU: 
67868(Cela3b)
RNO: 
298567(Cela3b)
CGE: 
HGL: 
101701010(Cela3b)
TUP: 
102489028(CELA3B)
CFA: 
478196(CELA3B)
AML: 
FCA: 
101094275(CELA3B)
BTA: 
281752(CELA3B)
BOM: 
PHD: 
CHX: 
CFR: 
102514000(CELA3B)
ECB: 
100071692(CELA3B)
MYB: 
102258274(CELA3B)
MDO: 
MGP: 
FAB: 
PHI: 
APLA: 
CLV: 
ACS: 
XLA: 
447029(cela3b)
XTR: 
TRU: 
XMA: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:234742]
  Authors
Mallory PA, Travis J.
  Title
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase.
  Journal
Biochemistry. 14 (1975) 722-30.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3477287]
  Authors
Shen WF, Fletcher TS, Largman C.
  Title
Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.
  Journal
Biochemistry. 26 (1987) 3447-52.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:23436]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
68073-27-8

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