KEGG   ENZYME: 3.4.21.73Help
Entry
EC 3.4.21.73                Enzyme                                 
Name
u-plasminogen activator;
urokinase;
urinary plasminogen activator;
cellular plasminogen activator;
urokinase-type plasminogen activator;
double-chain urokinase-type plasminogen activator;
two-chain urokinase-type plasminogen activator;
urokinase plasminogen activator;
uPA;
u-PA;
abbokinase;
urinary esterase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Specific cleavage of Arg!Val bond in plasminogen to form plasmin
Comment
Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26
Orthology
K01348  
urokinase plasminogen activator
Genes
HSA: 
5328(PLAU)
PTR: 
738078(PLAU)
PPS: 
100983615(PLAU)
GGO: 
101137500(PLAU)
PON: 
100171578(PLAU)
MCC: 
705853(PLAU)
MMU: 
18792(Plau)
RNO: 
25619(Plau)
CFA: 
403426(PLAU)
AML: 
FCA: 
101098338(PLAU)
BTA: 
281408(PLAU)
SSC: 
396985(PLAU)
ECB: 
100072886
MDO: 
100617123
SHR: 
100918318(PLAU)
OAA: 
100079618
GGA: 
396424(PLAU)
MGP: 
100541361
TGU: 
100228975(PLAU)
ACS: 
100552401
DRE: 
100538108(plaub)
TRU: 
101066245
OLA: 
100529199(plau) 101167229
 » show all
Taxonomy
Reference
1  [PMID:6210826]
  Authors
Lottenberg R, Christensen U, Jackson CM, Coleman PL.
  Title
Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
  Journal
Methods. Enzymol. 80 Pt C (1981) 341-61.
Reference
2  [PMID:3148826]
  Authors
Loskutoff DJ, Schleef RR.
  Title
Plasminogen activators and their inhibitors.
  Journal
Methods. Enzymol. 163 (1988) 293-302.
Reference
3  [PMID:3143380]
  Authors
Saksela O, Rifkin DB.
  Title
Cell-associated plasminogen activation: regulation and physiological functions.
  Journal
Annu. Rev. Cell. Biol. 4 (1988) 93-126.
Reference
4
  Authors
Collen, D., Lijnen, H. R. and Verstraete, M.
  Title
The fibrinolytic system and its disorders.
  Journal
In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.), Blood: Principles and Practice of Hematology, 2nd ed., J.B.Lippincott Company, Philadelphia, 1990.
Reference
5  [PMID:1969415]
  Authors
Lijnen HR, Van Hoef B, Nelles L, Collen D.
  Title
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu).
  Journal
J. Biol. Chem. 265 (1990) 5232-6.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9039-53-6
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