KEGG   ENZYME: 3.4.21.76Help
Entry
EC 3.4.21.76                Enzyme                                 
Name
myeloblastin;
leukocyte proteinase 3;
leukocyte proteinase 4;
Wegener's granulomatosis autoantigen;
proteinase PR-3;
proteinase-3;
PMNL proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val!
Comment
From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor
Orthology
K01350  
myeloblastin
Genes
HSA: 
5657(PRTN3)
PTR: 
749895(PRTN3)
GGO: 
101135765(PRTN3)
PON: 
100452422(PRTN3)
MCC: 
MMU: 
19152(Prtn3)
RNO: 
314615(Prtn3)
BTA: 
100298591(PRTN3)
ECB: 
MDO: 
SHR: 
100933022(PRTN3)
 » show all
Taxonomy
Reference
1  [PMID:1681549]
  Authors
Labbaye C, Musette P, Cayre YE.
  Title
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 9253-6.
  Organism
Homo sapiens [GN:hsa]
  Sequence
HSA: 5657
Reference
2  [PMID:2033050]
  Authors
Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR.
  Title
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.
  Journal
J. Biol. Chem. 266 (1991) 9540-8.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:1445363]
  Authors
Brubaker MJ, Groutas WC, Hoidal JR, Rao NV.
  Title
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters.
  Journal
Biochem. Biophys. Res. Commun. 188 (1992) 1318-24.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:1551417]
  Authors
Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC.
  Title
Substrate and inhibitor studies on proteinase 3.
  Journal
FEBS. Lett. 297 (1992) 119-23.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128028-50-2
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