KEGG   ENZYME: 3.4.21.79Help
Entry
EC 3.4.21.79                Enzyme                                 

Name
granzyme B;
CTLA1;
CCPII;
cytotoxic cell proteinase-1;
granzyme G;
granzyme H;
CCP1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: -Asp! >> -Asn! > -Met!, -Ser!
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.79 created 1993
Orthology
K01353  
granzyme B
Genes
HSA: 
3002(GZMB)
PTR: 
452825(GZMB)
PPS: 
100987153(GZMB)
GGO: 
101133374(GZMB)
PON: 
100432682(GZMB)
NLE: 
100604300(GZMB)
MCC: 
716518(GZMB)
MCF: 
102130260(GZMB)
CJC: 
100389206(GZMB)
MMU: 
14939(Gzmb)
RNO: 
100361468(Gzmbl2) 171528(Gzmb)
CGE: 
NGI: 
HGL: 
101702156(Gzmb)
OCU: 
TUP: 
CFA: 
490630(GZMB)
AML: 
UMR: 
FCA: 
PTG: 
102957957(GZMB)
BTA: 
281731(GZMB) 508646(GZMB)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
100015759(GZMB)
SHR: 
OAA: 
791103(GZMB)
ASN: 
AMJ: 
PSS: 
CMY: 
DRE: 
MZE: 
OLA: 
XMA: 
 » show all
Taxonomy
Reference
1  [PMID:2953813]
  Authors
Schmid J, Weissmann C.
  Title
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.
  Journal
J. Immunol. 139 (1987) 250-6.
  Sequence
[hsa:3002]
Reference
2  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry. 30 (1991) 2217-27.
Reference
3  [PMID:1985927]
  Authors
Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ.
  Title
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
  Journal
J. Biol. Chem. 266 (1991) 98-103.
  Sequence
[hsa:3002]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
143180-74-9

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