KEGG   ENZYME: 3.4.21.93Help
Entry
EC 3.4.21.93                Enzyme                                 

Name
proprotein convertase 1;
prohormone convertase 3;
neuroendocrine convertase 1;
PC1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.93 created 1996
Orthology
K01359  
proprotein convertase subtilisin/kexin type 1
Genes
HSA: 
5122(PCSK1)
PTR: 
461740(PCSK1)
PPS: 
100988619(PCSK1)
GGO: 
101129039(PCSK1)
PON: 
100173253(PCSK1)
MCC: 
699742(PCSK1)
MCF: 
102142243(PCSK1)
MMU: 
18548(Pcsk1)
RNO: 
CGE: 
100757402(Pcsk1)
HGL: 
101704290(Pcsk1)
TUP: 
CFA: 
479149(PCSK1)
AML: 
100484463(PCSK1)
FCA: 
101082627(PCSK1)
PTG: 
102971097(PCSK1)
BTA: 
281967(PCSK1)
BOM: 
102266289(PCSK1)
PHD: 
102340197(PCSK1)
CHX: 
102184429(PCSK1)
OAS: 
443029(PC1)
SSC: 
397103(PCSK1)
CFR: 
102510598(PCSK1)
BACU: 
103011823(PCSK1)
LVE: 
103072078(PCSK1)
ECB: 
100064886(PCSK1)
MYB: 
102259719(PCSK1)
MYD: 
102763458(PCSK1)
PALE: 
102890971(PCSK1)
MDO: 
100010673(PCSK1)
SHR: 
OAA: 
100081484(PCSK1)
GGA: 
769230(PCSK1)
TGU: 
100226064(PCSK1)
FAB: 
101816616(PCSK1)
PHI: 
102111185(PCSK1)
APLA: 
101796157(PCSK1)
FPG: 
101913861(PCSK1)
FCH: 
102048239(PCSK1)
CLV: 
102092106(PCSK1)
ASN: 
102377633(PCSK1)
AMJ: 
PSS: 
102461055(PCSK1)
CMY: 
102934087(PCSK1)
ACS: 
100565158(pcsk1)
PBI: 
103055161(PCSK1)
XTR: 
100496933(pcsk1)
DRE: 
100005716(pcsk1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
AME: 
410438(GB11271)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
NVE: 
HMG: 
TAD: 
 » show all
Taxonomy
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA. Cell. Biol. 9 (1990) 415-24.
  Sequence
[mmu:18548]
Reference
2  [PMID:1988934]
  Authors
Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DF.
  Title
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 340-4.
  Sequence
[up:P63240]
Reference
3  [PMID:1429684]
  Authors
Steiner DF, Smeekens SP, Ohagi S, Chan SJ.
  Title
The new enzymology of precursor processing endoproteases.
  Journal
J. Biol. Chem. 267 (1992) 23435-8.
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods. Enzymol. 244 (1994) 175-88.
Reference
5  [PMID:7741698]
  Authors
Jean F, Basak A, DiMaio J, Seidah NG, Lazure C.
  Title
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
  Journal
Biochem. J. 307 ( Pt 3) (1995) 689-95.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99676-46-7

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