KEGG   ENZYME: 3.4.22.10Help
Entry
EC 3.4.22.10                Enzyme                                 

Name
streptopain;
Streptococcus peptidase A;
streptococcal cysteine proteinase;
Streptococcus protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage with hydrophobic residues at P2, P1 and P1'
Comment
From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10.
History
EC 3.4.22.10 created 1961 as EC 3.4.4.18, transferred 1972 to EC 3.4.22.10
Orthology
K01364  
streptopain
Genes
SPY: 
SPy_2039(speB)
SPZ: 
SPM: 
SPG: 
SPS: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
SpyM51698(speB)
SPA: 
SPB: 
SOZ: 
FBR: 
 » show all
Taxonomy
Reference
1
  Authors
Elliott, S.D. and Liu, T.-Y.
  Title
Streptococcal proteinase.
  Journal
Methods Enzymol. 19 (1970) 252-261.
Reference
2
  Authors
Liu, T.-Y. and Elliott, S.D.
  Title
Streptococcal proteinase.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., Academic Press, New York, 1971, p. 609-647.
Reference
3  [PMID:1270417]
  Authors
Tai JY, Kortt AA, Liu TY, Elliott SD.
  Title
Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain.
  Journal
J. Biol. Chem. 251 (1976) 1955-9.
  Organism
Streptococcus pyogenes
  Sequence
[spy:SPy_2039]
Reference
4  [PMID:6381494]
  Authors
Lo SS, Fraser BA, Liu TY.
  Title
The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis.
  Journal
J. Biol. Chem. 259 (1984) 11041-5.
  Organism
Streptococcus pyogenes
  Sequence
[spy:SPy_2039]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-51-8

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