KEGG   ENZYME: 3.4.22.15Help
Entry
EC 3.4.22.15                Enzyme                                 

Name
cathepsin L;
Aldrichina grahami cysteine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Comment
A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64
History
EC 3.4.22.15 created 1978 (EC 3.4.99.19 created 1972, incorporated 1981)
Orthology
K01365  
cathepsin L
Genes
HSA: 
1514(CTSL)
PTR: 
737449(CTSL1)
PPS: 
100987260(CTSL1)
GGO: 
PON: 
100450374(CTSL1)
NLE: 
100604414(CTSL1)
MCC: 
MCF: 
CJC: 
100412536(CTSL)
MMU: 
13039(Ctsl)
RNO: 
25697(Ctsl)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
UMR: 
103682224(CTSV)
FCA: 
PTG: 
BTA: 
281108(CTSV) 515200(CTSL1)
BOM: 
PHD: 
CHX: 
OAS: 
780510(CTSL2)
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
420160 427466(CTSL2)
MGP: 
APLA: 
101803168(CTSL1)
TGU: 
FAB: 
101814636(CTSL)
PHI: 
102099328(CTSL)
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
100561941(ctsl)
PBI: 
XLA: 
447313(ctsv)
XTR: 
448179(ctsv)
DRE: 
30443(ctsl1b) 321453(ctsla)
TRU: 
MZE: 
OLA: 
100049246(ctsl)
XMA: 
LCM: 
CMK: 
103188176(ctsl)
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552756(GB19923)
NVI: 
BMOR: 
693031(Bcp)
API: 
100166071(Ctsl)
PHU: 
CEL: 
CBR: 
CBG22599(Cbr-cpl-1)
BMY: 
LOA: 
NVE: 
HMG: 
TAD: 
AQU: 
MTR: 
OLU: 
OTA: 
MBR: 
DDI: 
DPP: 
EDI: 
ACAN: 
TET: 
PTI: 
TPS: 
GTT: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:7043200]
  Authors
Barrett AJ, Kirschke H.
  Title
Cathepsin B, Cathepsin H, and cathepsin L.
  Journal
Methods. Enzymol. 80 Pt C (1981) 535-61.
Reference
2
  Authors
Barrett, A.J., Buttle, D.J. and Mason, R.W.
  Title
Lysosomal cysteine proteinases.
  Journal
ISI Atlas of Science. Biochemistry 1 (1988) 256-260.
Reference
3  [PMID:2835398]
  Authors
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP.
  Title
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.
  Journal
J. Clin. Invest. 81 (1988) 1621-9.
  Sequence
[hsa:1514] [mmu:13039]
Reference
4  [PMID:3342870]
  Authors
Kirschke H, Wikstrom P, Shaw E.
  Title
Active center differences between cathepsins L and B: the S1 binding region.
  Journal
FEBS. Lett. 228 (1988) 128-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
60616-82-2

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