| Entry |
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| Name |
papain;
papayotin;
summetrin;
velardon;
papaine;
Papaya peptidase I
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
 |
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| Reaction(IUBMB) |
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'
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| Comment |
Type example of peptidase family C1 from latex of the papaya (Carica papaya) fruit. Inhibited by compound E-64 and proteins of the cystatin family.
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| Orthology |
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| Genes |
 |
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| Reference |
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| Authors |
Kamphuis IG, Drenth J, Baker EN. |
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| Title |
Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain. |
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| Journal |
J. Mol. Biol. 182 (1985) 317-29. |
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| Organism |
Carica papaya, Actinidia chinensis |
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| Reference |
2 |
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| Authors |
Menard, R. and Storer, A.C. |
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| Title |
Papain. |
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| Journal |
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 555-557. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9001-73-4 |
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