| Entry |
|
|---|
| Name |
glycyl endopeptidase;
papaya peptidase B;
papaya proteinase IV;
glycine-specific proteinase;
chymopapain;
Papaya proteinase 4;
PPIV;
chymopapain M
|
|---|
| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
 |
|---|
| Reaction(IUBMB) |
Preferential cleavage: Gly!, in proteins and small molecule substrates
|
|---|
| Comment |
From the papaya plant, Carica papaya. Not inhibited by chicken cystatin, unlike most other homologues of papain, but in peptidase family C1 (papain family)
|
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| Reference |
|
|---|
| Authors |
Polgar L. |
|---|
| Title |
Isolation of highly active papaya peptidases A and B from commercial chymopapain. |
|---|
| Journal |
Biochim. Biophys. Acta. 658 (1981) 262-9. |
|---|
| Organism |
Carica papaya |
|---|
| Reference |
|
|---|
| Authors |
Buttle DJ, Kembhavi AA, Sharp SL, Shute RE, Rich DH, Barrett AJ. |
|---|
| Title |
Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex. |
|---|
| Journal |
Biochem. J. 261 (1989) 469-76. |
|---|
| Organism |
Carica papaya |
|---|
| Reference |
|
|---|
| Authors |
Ritonja A, Buttle DJ, Rawlings ND, Turk V, Barrett AJ. |
|---|
| Title |
Papaya proteinase IV amino acid sequence. |
|---|
| Journal |
FEBS. Lett. 258 (1989) 109-12. |
|---|
| Organism |
Carica papaya |
|---|
| Reference |
|
|---|
| Authors |
Buttle DJ, Ritonja A, Pearl LH, Turk V, Barrett AJ |
|---|
| Title |
Selective cleavage of glycyl bonds by papaya proteinase IV. |
|---|
| Journal |
FEBS. Lett. 260 (1990) 195-7. |
|---|
| Reference |
|
|---|
| Authors |
Buttle DJ, Ritonja A, Dando PM, Abrahamson M, Shaw EN, Wikstrom P, Turk V, Barrett AJ. |
|---|
| Title |
Interactions of papaya proteinase IV with inhibitors. |
|---|
| Journal |
FEBS. Lett. 262 (1990) 58-60. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 149719-24-4 |
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