KEGG   ENZYME: 3.4.22.27Help
Entry
EC 3.4.22.27                Enzyme                                 

Name
cathepsin S
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to cathepsin L, but with much less activity on Z-Phe-Arg!NHMec, and more activity on the Z-Val-Val-Arg! compound
Comment
A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)
History
EC 3.4.22.27 created 1992
Orthology
K01368  
cathepsin S
Genes
HSA: 
1520(CTSS)
PTR: 
457277(CTSS)
PPS: 
100975000(CTSS)
GGO: 
101141942(CTSS)
PON: 
100432810(CTSS)
MCC: 
MCF: 
102120796(CTSS)
MMU: 
13040(Ctss)
RNO: 
50654(Ctss)
CGE: 
HGL: 
101697008(Ctss)
TUP: 
102469586(CTSS)
CFA: 
403400(CTSS)
AML: 
FCA: 
101083283(CTSS)
BTA: 
327711(CTSS)
BOM: 
102287237(CTSS)
PHD: 
102332752(CTSS)
CHX: 
102183747(CTSS)
SSC: 
100153090(CTSS)
CFR: 
102510939(CTSS)
ECB: 
100054948(CTSS)
MYB: 
102259811(CTSS)
MDO: 
SHR: 
100917184(CTSS)
GGA: 
425657(CTSS)
FAB: 
PHI: 
APLA: 
101794564(CTSS)
FPG: 
101911722(CTSS)
FCH: 
102055558(CTSS)
CLV: 
102094330(CTSS)
ASN: 
PSS: 
102458936(CTSS)
ACS: 
XLA: 
380516(ctss-a) 398927 446505(ctss-b)
XTR: 
DRE: 
337572(ctssb.2) 393398(ctssa) 554157(ctssb.1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
PTM: 
 » show all
Taxonomy
Reference
1  [PMID:1182153]
  Authors
Turnsek T, Kregar I, Lebez D.
  Title
Acid sulphydryl protease from calf lymph nodes.
  Journal
Biochim. Biophys. Acta. 403 (1975) 514-20.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:2604727]
  Authors
Bromme D, Steinert A, Friebe S, Fittkau S, Wiederanders B, Kirschke H.
  Title
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.
  Journal
Biochem. J. 264 (1989) 475-81.
  Organism
Rattus norvegicus [GN:rno]
  Sequence
[bta:327711]
Reference
3  [PMID:2690828]
  Authors
Kirschke H, Wiederanders B, Bromme D, Rinne A.
  Title
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.
  Journal
Biochem. J. 264 (1989) 467-73.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71965-46-3

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