picornain 3C;
picornavirus endopeptidase 3C;
poliovirus protease 3C;
rhinovirus protease 3C;
foot-and-mouth protease 3C;
poliovirus proteinase 3C;
rhinovirus proteinase 3C;
coxsackievirus 3C proteinase;
foot-and-mouth-disease virus proteinase 3C;
3C protease;
3C proteinase;
cysteine proteinase 3C;
hepatitis A virus 3C proteinase;
protease 3C;
tomato ringspot nepovirus 3C-related protease

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Selective cleavage of Gln!Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly

From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3

1  [PMID:3016701]

Ivanoff LA, Towatari T, Ray J, Korant BD, Petteway SR Jr.

Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.

Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 5392-6.

poliovirus

2  [PMID:3186696]

Bazan JF, Fletterick RJ.

Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.

Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7872-6.

poliovirus

3  [PMID:3052288]

Krausslich HG, Wimmer E.

Viral proteinases.

Annu. Rev. Biochem. 57 (1988) 701-54.

4  [PMID:2846872]

Nicklin MJ, Harris KS, Pallai PV, Wimmer E.

Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.

J. Virol. 62 (1988) 4586-93.

poliovirus