KEGG   ENZYME: 3.4.22.31Help
Entry
EC 3.4.22.31                Enzyme                                 

Name
ananain;
stem bromelain;
fruit bromelain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-Arg!NHMec, but broader specificity than fruit bromelain
Comment
From stem of pineapple plant, Ananas comosus. Differs from stem and fruit bromelains in being inhibited by chicken cystatin. In peptidase family C1 (papain family)
History
EC 3.4.22.31 created 1992
Reference
1  [PMID:3196029]
  Authors
Rowan AD, Buttle DJ, Barrett AJ.
  Title
Ananain: a novel cysteine proteinase found in pineapple stem.
  Journal
Arch. Biochem. Biophys. 267 (1988) 262-70.
  Organism
Ananas comosus
Reference
2  [PMID:2327970]
  Authors
Rowan AD, Buttle DJ, Barrett AJ.
  Title
The cysteine proteinases of the pineapple plant.
  Journal
Biochem. J. 266 (1990) 869-75.
  Organism
Ananas comosus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
119129-70-3

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