| Entry |
|
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| Name |
stem bromelain;
bromelain;
pineapple stem bromelain
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
 |
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| Reaction(IUBMB) |
Broad specificity for cleavage of proteins, but strong preference for Z-Arg-Arg!NHMec amongst small molecule substrates
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| Comment |
The most abundant of the cysteine endopeptidases of the stem of the pineapple plant, Ananas comosus. Distinct from the bromelain found in the pineapple fruit (EC 3.4.22.33). Scarcely inhibited by chicken cystatin and also very slowly inactivated by {glossary/E64::E-64}. In peptidase family C1 (papain family).
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| Reference |
1 |
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| Authors |
Brocklehurst, K., Willenbrock, F. and Salih, E. |
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| Title |
Cysteine proteinases. |
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| Journal |
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, Elsevier, Amsterdam, 1987, p. 39-158. |
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| Reference |
|
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| Authors |
Rowan AD, Buttle DJ, Barrett AJ. |
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| Title |
Ananain: a novel cysteine proteinase found in pineapple stem. |
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| Journal |
Arch. Biochem. Biophys. 267 (1988) 262-70. |
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| Organism |
Ananas comosus |
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| Reference |
|
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| Authors |
Ritonja A, Rowan AD, Buttle DJ, Rawlings ND, Turk V, Barrett AJ. |
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| Title |
Stem bromelain: amino acid sequence and implications for weak binding of cystatin. |
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| Journal |
FEBS. Lett. 247 (1989) 419-24. |
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| Organism |
Ananas comosus |
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| Reference |
|
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| Authors |
Rowan AD, Buttle DJ, Barrett AJ. |
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| Title |
The cysteine proteinases of the pineapple plant. |
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| Journal |
Biochem. J. 266 (1990) 869-75. |
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| Organism |
Ananas comosus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37189-34-7 |
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