fruit bromelain;
juice bromelain;
ananase;
bromelase;
bromelin;
extranase;
juice bromelain;
pinase;
pineapple enzyme;
traumanase;
fruit bromelain FA2

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg!NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain)

From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin [4].

1  [PMID:4127920]

Sasaki M, Kato T, Iida S.

Antigenic determinant common to four kinds of thiol proteases of plant origin.

J. Biochem. (Tokyo). 74 (1973) 635-7.

2  [PMID:956152]

Yamada F, Takahashi N, Murachi T.

Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2.

J. Biochem. (Tokyo). 79 (1976) 1223-34.

Ananas comosus

3  [PMID:4044551]

Ota S, Muta E, Katahira Y, Okamoto Y.

Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains.

J. Biochem. (Tokyo). 98 (1985) 219-28.

4  [PMID:2327970]

Rowan AD, Buttle DJ, Barrett AJ.

The cysteine proteinases of the pineapple plant.

Biochem. J. 266 (1990) 869-75.

Ananas comosus