KEGG   ENZYME: 3.4.22.34Help
Entry
EC 3.4.22.34                Enzyme                                 

Name
legumain;
asparaginyl endopeptidase;
citvac;
proteinase B (ambiguous);
hemoglobinase (ambiguous);
PRSC1 gene product (Homo sapiens);
vicilin peptidohydrolase;
bean endopeptidase;
vicilin peptidohydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins and small molecule substrates at -Asn!Xaa- bonds
Comment
Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13
History
EC 3.4.22.34 created 1992, modified 2000
Orthology
K01369  
legumain
Genes
HSA: 
5641(LGMN)
PTR: 
453118(LGMN)
PPS: 
100979480(LGMN)
GGO: 
101136467(LGMN)
PON: 
100173793(LGMN)
MCC: 
703734(LGMN)
MCF: 
101867471(LGMN)
MMU: 
19141(Lgmn)
RNO: 
63865(Lgmn)
CGE: 
100752348(Lgmn)
HGL: 
101698288(Lgmn)
TUP: 
102474276(LGMN)
CFA: 
480232(LGMN)
AML: 
FCA: 
101098470(LGMN)
PTG: 
102969813(LGMN)
BTA: 
281281(LGMN)
BOM: 
102279974(LGMN)
PHD: 
102332201(LGMN)
CHX: 
102191183(LGMN)
SSC: 
CFR: 
102509831(LGMN)
BACU: 
103013176(LGMN)
LVE: 
103083212(LGMN)
ECB: 
100053265(LGMN)
MYB: 
102254818(LGMN)
MYD: 
102768828(LGMN)
PALE: 
102889046(LGMN)
MDO: 
100016534(LGMN)
SHR: 
OAA: 
100079679(LGMN)
GGA: 
423418(LGMN)
MGP: 
TGU: 
100220965(LGMN)
FAB: 
101806290(LGMN)
PHI: 
102106609(LGMN)
APLA: 
101801019(LGMN)
FPG: 
101914771(LGMN)
FCH: 
102057063(LGMN)
CLV: 
102094176(LGMN)
ASN: 
102373928(LGMN)
AMJ: 
102570177(LGMN)
PSS: 
102451298(LGMN)
CMY: 
102947732(LGMN)
ACS: 
PBI: 
103052653(LGMN)
XLA: 
379601(lgmn)
XTR: 
448252(lgmn)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350037(LGMN)
CMK: 
BFO: 
CIN: 
SPU: 
API: 
ISC: 
CEL: 
CELE_T28H10.3(T28H10.3)
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
AT1G62710(BETA-VPE) AT2G25940(ALPHA-VPE) AT3G20210(DELTA-VPE) AT4G32940(GAMMA-VPE)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0001s07710g POPTR_0003s11280g(POPTRDRAFT_817294) POPTR_0006s24900g(POPTRDRAFT_653937) POPTR_0008s00410g(POPTRDRAFT_873719) POPTR_0018s04650g(POPTRDRAFT_736805)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0559600-01(Os01g0559600) Os02t0644000-01(Os02g0644000) Os04t0537900-01(Os04g0537900) Os05t0593900-01(Os05g0593900) Os06t0105100-00(Os06g0105100)
OBR: 
BDI: 
SBI: 
SORBI_03g025440(SORBIDRAFT_03g025440) SORBI_04g033520(SORBIDRAFT_04g033520) SORBI_06g023820(SORBIDRAFT_06g023820) SORBI_09g030710(SORBIDRAFT_09g030710)
ZMA: 
100192667 100286140(pco079297) 100856894(see2a) 542001(see2a) 542077(vpe1) 542609(pco131778b)
SITA: 
ATR: 
s00002p00230280(AMTR_s00002p00230280) s00002p00230380(AMTR_s00002p00230380) s00002p00231730(AMTR_s00002p00231730) s00036p00187360(AMTR_s00036p00187360)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
TET: 
PTM: 
PIF: 
EHX: 
GTT: 
NGR: 
TVA: 
 » show all
Taxonomy
Reference
1
  Authors
Hara-Nishimura, I.
  Title
Asparaginyl endopeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 746-749.
Reference
2
  Authors
Dalton, J.P. and Brindley, P.J.
  Title
Schistosome legumain.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 749-754.
Reference
3  [PMID:9891971]
  Authors
Chen JM, Rawlings ND, Stevens RA, Barrett AJ.
  Title
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
  Journal
FEBS. Lett. 441 (1998) 361-5.
  Organism
Homo sapiens, Mus musculus
  Sequence
[mmu:19141]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149371-18-6

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