KEGG   ENZYME: 3.4.22.37Help
Entry
EC 3.4.22.37                Enzyme                                 

Name
gingipain R;
Arg-gingipain;
gingipain-1;
argingipain;
Arg-gingivain-55 proteinase;
Arg-gingivain-70 proteinase;
Arg-gingivain-75 proteinase;
arginine-specific cysteine protease;
arginine-specific gingipain;
arginine-specific gingivain;
RGP-1;
RGP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1
Comment
A secreted endopeptidase from the bacterium Porphyromonas gingivalis. Strongly activated by glycine [1], and stabilized by Ca2+. Precursor molecule contains a hemagglutinin domain [2,3]. Misleadingly described in some literature as "trypsin-like", being a cysteine peptidase, type example of family C25
History
EC 3.4.22.37 created 1996
Orthology
K08589  
gingipain R
Genes
PGI: 
PG0506(prtRII) PG2024(hagE)
PGN: 
PGN_1466(rgpB) PGN_1970(rgpA)
Taxonomy
Reference
1  [PMID:1527017]
  Authors
Chen Z, Potempa J, Polanowski A, Wikstrom M, Travis J.
  Title
Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis.
  Journal
J. Biol. Chem. 267 (1992) 18896-901.
  Sequence
[pgi:PG2024]
Reference
2  [PMID:7857299]
  Authors
Kirszbaum L, Sotiropoulos C, Jackson C, Cleal S, Slakeski N, Reynolds EC.
  Title
Complete nucleotide sequence of a gene prtR of Porphyromonas gingivalis W50 encoding a 132 kDa protein that contains an arginine-specific thiol endopeptidase domain and a haemagglutinin domain.
  Journal
Biochem. Biophys. Res. Commun. 207 (1995) 424-31.
Reference
3  [PMID:7836351]
  Authors
Pavloff N, Potempa J, Pike RN, Prochazka V, Kiefer MC, Travis J, Barr PJ.
  Title
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein.
  Journal
J. Biol. Chem. 270 (1995) 1007-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
159745-71-8

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