KEGG   ENZYME: 3.4.22.38Help
Entry
EC 3.4.22.38                Enzyme                                 
Name
cathepsin K;
cathepsin O and cathepsin X (both misleading, having been used for other enzymes);
cathepsin O2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg
Comment
Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)
Orthology
K01371  
cathepsin K
Genes
HSA: 
1513(CTSK)
PTR: 
457278(CTSK)
PPS: 
100974656(CTSK)
GGO: 
101145486(CTSK)
PON: 
100432447(CTSK)
MCC: 
574112(CTSK)
MMU: 
13038(Ctsk)
RNO: 
29175(Ctsk)
CFA: 
608843(CTSK)
AML: 
FCA: 
101093379(CTSK)
BTA: 
513038(CTSK)
SSC: 
397569(CTSK)
ECB: 
100054991
MDO: 
100017449
SHR: 
100917440(CTSK)
OAA: 
100088286
GGA: 
395818(CTSK)
ACS: 
100561728
XLA: 
100127265(ctsk)
XTR: 
448216(ctsk) 779889(ctsk)
DRE: 
550475(ctsk)
TRU: 
101066261
OLA: 
101164922
DME: 
Dmel_CG4847
DAN: 
Dana_GF13132
TCA: 
658343 660669
BMY: 
Bm1_13265
 » show all
Taxonomy
Reference
1  [PMID:7818555]
  Authors
Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.
  Title
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
  Journal
Biochem. Biophys. Res. Commun. 206 (1995) 89-96.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:8647860]
  Authors
Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.
  Title
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
  Journal
J. Biol. Chem. 271 (1996) 12517-24.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:8670136]
  Authors
Bromme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.
  Title
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.
  Journal
Biochem. J. 315 ( Pt 1) (1996) 85-9.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:9033588]
  Authors
Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS.
  Title
Crystal structure of human osteoclast cathepsin K complex with E-64.
  Journal
Nat. Struct. Biol. 4 (1997) 109-11.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:9033587]
  Authors
McGrath ME, Klaus JL, Barnes MG, Bromme D.
  Title
Crystal structure of human cathepsin K complexed with a potent inhibitor.
  Journal
Nat. Struct. Biol. 4 (1997) 105-9.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94716-09-3
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