KEGG   ENZYME: 3.4.22.41Help
Entry
EC 3.4.22.41                Enzyme                                 

Name
cathepsin F
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
Comment
Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3
History
EC 3.4.22.41 created 2000
Orthology
K01373  cathepsin F
Genes
HSA: 8722(CTSF)
PTR: 746579(CTSF)
PPS: 100975299(CTSF)
GGO: 101129359(CTSF)
PON: 100439389(CTSF)
NLE: 100597028(CTSF)
MCC: 713743(CTSF)
MCF: 102124998(CTSF)
CSAB: 103222435(CTSF)
RRO: 104664768(CTSF)
RBB: 108518671(CTSF)
CJC: 100398631(CTSF)
SBQ: 101029299(CTSF)
MMU: 56464(Ctsf)
RNO: 361704(Ctsf)
CGE: 100756958(Ctsf)
NGI: 103725560(Ctsf)
HGL: 101719972(Ctsf)
CCAN: 109687122(Ctsf)
OCU: 100101596(CTSF)
TUP: 102480161(CTSF)
CFA: 476010(CTSF)
AML: 100483888(CTSF)
UMR: 103679601(CTSF)
ORO: 101365457(CTSF)
FCA: 101099835(CTSF)
PTG: 102948473(CTSF)
AJU: 106971117(CTSF)
BTA: 509715(CTSF)
BOM: 102282298(CTSF)
BIU: 109554136(CTSF)
PHD: 102336699(CTSF)
CHX: 102178045(CTSF)
OAS: 780471(CTSF)
SSC: 100520004(CTSF)
CFR: 102505263(CTSF)
CDK: 105104453(CTSF)
BACU: 103010911(CTSF)
LVE: 103073241(CTSF)
OOR: 101278493(CTSF)
ECB: 100058569(CTSF)
EPZ: 103559688(CTSF)
EAI: 106833524(CTSF)
MYB: 102241833(CTSF)
MYD: 102766674(CTSF)
HAI: 109384299(CTSF)
PALE: 102897590(CTSF)
LAV: 100676928(CTSF)
TMU: 101350738
MDO: 100029564(CTSF)
SHR: 100927375(CTSF)
ASN: 102372605(CTSF)
AMJ: 102558774(CTSF)
PSS: 102454736
CMY: 102938008
CPIC: 101935122(CTSF)
ACS: 103283025
PVT: 110088139(CTSF)
GJA: 107107966(CTSF)
XLA: 108713957(ctsf.L)
XTR: 100127591(ctsf)
NPR: 108801968
DRE: 565588(ctsf)
IPU: 108268834(ctsw)
AMEX: 103042155
TRU: 101075977(ctsw)
LCO: 104939385(ctsf)
NCC: 104942321(ctsw)
MZE: 101469506
OLA: 101161416
XMA: 102233955
PRET: 103471043
NFU: 107381272
CSEM: 103391298
LCF: 108878763
HCQ: 109515785
BPEC: 110153922
SASA: 100195177(ctsw) 106612102(CATF)
ELS: 105026738
SFM: 108925299
LCM: 102345521 102362412(CTSW)
CIN: 100175491
SPU: 586859
APLC: 110988372
SKO: 100368277
DME: Dmel_CG12163(CG12163)
DSI: Dsimw501_GD19635(Dsim_GD19635)
MDE: 101890771
AME: 408851(GB13004)
BIM: 100745708
BTER: 100652275
SOC: 105202727
AEC: 105144905
ACEP: 105620305
PBAR: 105426056
HST: 105186896
CFO: 105253881
LHU: 105672877
PGC: 109858737
NVI: 100123649
TCA: 662417
DPA: 109546888
NVL: 108567845
BMOR: 101741510
API: 100158959(Ctsf)
DNX: 107162259
ZNE: 110831681
FCD: 110859207
CEL: CELE_F41E6.6(tag-196)
CBR: CBG01480(Cbr-tag-196)
SHX: MS3_01705
EPA: 110235917
AQU: 100631657
LJA: Lj0g3v0259509.1(Lj0g3v0259509.1) Lj0g3v0259509.2(Lj0g3v0259509.2) Lj0g3v0314599.1(Lj0g3v0314599.1) Lj1g3v2140860.1(Lj1g3v2140860.1) Lj3g3v0129310.1(Lj3g3v0129310.1) Lj3g3v0129320.1(Lj3g3v0129320.1) Lj3g3v3375960.1(Lj3g3v3375960.1) Lj3g3v3375970.1(Lj3g3v3375970.1) Lj5g3v1794680.1(Lj5g3v1794680.1)
DOSA: Os02t0469600-01(Os02g0469600) Os04t0311400-01(Os04g0311400) Os07t0480900-01(Os07g0480900)
ATS: 109734944(LOC109734944) 109740709(LOC109740709) 109764551(LOC109764551)
ZMA: 107305675 542701(ccp1)
MIS: MICPUN_98307(CP)
DFA: DFA_10113
SMIN: v1.2.007447.t1(symbB.v1.2.007447.t1)
 » show all
Taxonomy
Reference
1  [PMID:10318784]
  Authors
Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C.
  Title
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.
  Journal
J. Biol. Chem. 274 (1999) 13800-9.
  Sequence
[hsa:8722]
Reference
2  [PMID:10198209]
  Authors
Nagler DK, Sulea T, Menard R.
  Title
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.
  Journal
Biochem. Biophys. Res. Commun. 257 (1999) 313-8.
  Sequence
[hsa:8722]
Reference
3  [PMID:10362521]
  Authors
Wex T, Levy B, Wex H, Bromme D.
  Title
Human cathepsins F and W: A new subgroup of cathepsins.
  Journal
Biochem. Biophys. Res. Commun. 259 (1999) 401-7.
  Sequence
[hsa:8722]
Reference
4  [PMID:9822672]
  Authors
Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D.
  Title
Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
  Journal
J. Biol. Chem. 273 (1998) 32000-8.
  Sequence
[hsa:8722]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.41
IUBMB Enzyme Nomenclature: 3.4.22.41
ExPASy - ENZYME nomenclature database: 3.4.22.41
BRENDA, the Enzyme Database: 3.4.22.41
CAS: 65997-74-2

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