KEGG   ENZYME: 3.4.22.41Help
Entry
EC 3.4.22.41                Enzyme                                 

Name
cathepsin F
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
Comment
Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3
History
EC 3.4.22.41 created 2000
Orthology
K01373  
cathepsin F
Genes
HSA: 
8722(CTSF)
PTR: 
746579(CTSF)
PPS: 
100975299(CTSF)
GGO: 
101129359(CTSF)
PON: 
100439389(CTSF)
MCF: 
102124998(CTSF)
MMU: 
56464(Ctsf)
RNO: 
361704(Ctsf)
CGE: 
100756958(Ctsf)
HGL: 
101719972(Ctsf)
TUP: 
102480161(CTSF)
CFA: 
476010(CTSF)
AML: 
100483888(CTSF)
FCA: 
101099835(CTSF)
PTG: 
102948473(CTSF)
BTA: 
509715(CTSF)
BOM: 
102282298(CTSF)
PHD: 
102336699(CTSF)
CHX: 
102178045(CTSF)
SSC: 
CFR: 
102505263(CTSF)
BACU: 
103010911(CTSF)
LVE: 
103073241(CTSF)
ECB: 
100058569(CTSF)
MYB: 
102241833(CTSF)
MYD: 
102766674(CTSF)
PALE: 
102897590(CTSF)
MDO: 
100029564(CTSF)
SHR: 
100927375(CTSF)
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
XTR: 
100127591(ctsf)
DRE: 
565588(ctsf)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408851(GB13004)
NVI: 
TCA: 
API: 
100158959(Ctsf)
PHU: 
CEL: 
CELE_F41E6.6(tag-196)
CBR: 
CBG01480(Cbr-tag-196)
LOA: 
TSP: 
SMM: 
NVE: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0002s03020g(POPTRDRAFT_816035) POPTR_0004s16740g(POPTRDRAFT_648662) POPTR_0005s25540g(POPTRDRAFT_652004) POPTR_0008s033301 POPTR_0009s12420g(POPTRDRAFT_833041) POPTR_0010s23510g(POPTRDRAFT_886026)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0469600-01(Os02g0469600) Os04t0311400-01(Os04g0311400) Os07t0480900-01(Os07g0480900)
OBR: 
BDI: 
SBI: 
SORBI_02g033270(SORBIDRAFT_02g033270) SORBI_04g017830(SORBIDRAFT_04g017830)
ZMA: 
542701(ccp1)
SITA: 
ATR: 
s00001p00114210(AMTR_s00001p00114210) s00022p00251800(AMTR_s00022p00251800)
SMO: 
PPP: 
OLU: 
OTA: 
MIS: 
MPP: 
BPG: 
DDI: 
DPP: 
DFA: 
ACAN: 
TET: 
EHX: 
TCR: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:10318784]
  Authors
Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C.
  Title
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.
  Journal
J. Biol. Chem. 274 (1999) 13800-9.
  Organism
Homo sapiens
  Sequence
[hsa:8722]
Reference
2  [PMID:10198209]
  Authors
Nagler DK, Sulea T, Menard R.
  Title
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.
  Journal
Biochem. Biophys. Res. Commun. 257 (1999) 313-8.
  Organism
Homo sapiens
  Sequence
[hsa:8722]
Reference
3  [PMID:10362521]
  Authors
Wex T, Levy B, Wex H, Bromme D.
  Title
Human cathepsins F and W: A new subgroup of cathepsins.
  Journal
Biochem. Biophys. Res. Commun. 259 (1999) 401-7.
  Organism
Homo sapiens
  Sequence
[hsa:8722]
Reference
4  [PMID:9822672]
  Authors
Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D.
  Title
Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
  Journal
J. Biol. Chem. 273 (1998) 32000-8.
  Organism
Homo sapiens
  Sequence
[hsa:8722]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65997-74-2

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