KEGG   ENZYME: 3.4.22.42Help
Entry
EC 3.4.22.42                Enzyme                                 

Name
cathepsin O
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec
Comment
Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32
History
EC 3.4.22.42 created 2000
Orthology
K01374  
cathepsin O
Genes
HSA: 
1519(CTSO)
PTR: 
461567(CTSO)
PPS: 
100983673(CTSO)
GGO: 
101142847(CTSO)
PON: 
100435624(CTSO)
MCC: 
699868(CTSO)
MCF: 
102131405(CTSO)
MMU: 
229445(Ctso)
RNO: 
CGE: 
HGL: 
101724540(Ctso)
TUP: 
102482353(CTSO)
CFA: 
482665(CTSO)
AML: 
FCA: 
101090686(CTSO)
BTA: 
616804(CTSO)
BOM: 
102282130(CTSO)
PHD: 
102331870(CTSO)
CHX: 
102168847(CTSO)
SSC: 
100737564(CTSO)
ECB: 
100069500(CTSO)
MYB: 
102249484(CTSO)
MDO: 
SHR: 
OAA: 
GGA: 
422410(CTSO)
MGP: 
TGU: 
FAB: 
PHI: 
102100585(CTSO)
APLA: 
101789467(CTSO)
FPG: 
101915196(CTSO)
FCH: 
102048194(CTSO)
CLV: 
102091575(CTSO)
ASN: 
102388157(CTSO)
PSS: 
102452066(CTSO)
ACS: 
XTR: 
100496370(ctso)
DRE: 
567333(ctso)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346436(CTSO)
BFO: 
SPU: 
AGA: 
AAG: 
AME: 
551290(GB12963)
NVI: 
TCA: 
BMOR: 
API: 
ISC: 
NVE: 
HMG: 
TAD: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:9790772]
  Authors
Santamaria I, Pendas AM, Velasco G, Lopez-Otin C.
  Title
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
  Journal
Genomics. 53 (1998) 231-4.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:7929457]
  Authors
Velasco G, Ferrando AA, Puente XS, Sanchez LM, Lopez-Otin C.
  Title
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
  Journal
J. Biol. Chem. 269 (1994) 27136-42.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:1519]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162032-86-2

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