KEGG   ENZYME: 3.4.22.42Help
Entry
EC 3.4.22.42                Enzyme                                 
Name
cathepsin O
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec
Comment
Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32
Orthology
K01374  
cathepsin O
Genes
HSA: 
1519(CTSO)
PTR: 
461567(CTSO)
PPS: 
100983673(CTSO)
GGO: 
101142847(CTSO)
PON: 
100435624(CTSO)
MCC: 
699868(CTSO)
MMU: 
229445(Ctso)
RNO: 
CFA: 
482665(CTSO)
AML: 
FCA: 
101090686(CTSO)
BTA: 
616804(CTSO)
SSC: 
100737564
ECB: 
100069500
MDO: 
100023827
SHR: 
100928401
OAA: 
100079864
GGA: 
422410(CTSO)
MGP: 
100547831
TGU: 
100217754(CTSO) 100224161
ACS: 
100562623
XTR: 
100496370
DRE: 
567333(ctso)
TRU: 
101061735
OLA: 
101169673
BFO: 
BRAFLDRAFT_210717
SPU: 
593754
AGA: 
AgaP_AGAP002720
AAG: 
AaeL_AAEL000420
AME: 
551290
NVI: 
100114880(NV17831)
TCA: 
659087
API: 
100572803
ISC: 
IscW_ISCW017550
NVE: 
NEMVE_v1g125012
HMG: 
100199722
TAD: 
TRIADDRAFT_20325
MBR: 
MONBRDRAFT_22706
 » show all
Taxonomy
Reference
1  [PMID:9790772]
  Authors
Santamaria I, Pendas AM, Velasco G, Lopez-Otin C.
  Title
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
  Journal
Genomics. 53 (1998) 231-4.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:7929457]
  Authors
Velasco G, Ferrando AA, Puente XS, Sanchez LM, Lopez-Otin C.
  Title
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
  Journal
J. Biol. Chem. 269 (1994) 27136-42.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162032-86-2
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