KEGG   ENZYME: 3.4.22.43Help
Entry
EC 3.4.22.43                Enzyme                                 

Name
cathepsin V;
Cathepsin L2;
cathepsin U
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Comment
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2
History
EC 3.4.22.43 created 2000
Orthology
K01375  
cathepsin V
Genes
HSA: 
1515(CTSV)
PTR: 
464593(CTSL2)
PPS: 
100974568(CTSL2)
GGO: 
101143768(CTSL2)
PON: 
100439744(CTSL2)
MCC: 
710850(CTSL2)
MCF: 
102134104(CTSV)
Taxonomy
Reference
1  [PMID:10029531]
  Authors
Bromme D, Li Z, Barnes M, Mehler E.
  Title
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
  Journal
Biochemistry. 38 (1999) 2377-85.
  Organism
Homo sapiens
  Sequence
[hsa:1515]
Reference
2  [PMID:9727401]
  Authors
Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K.
  Title
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.
  Journal
Invest. Ophthalmol. Vis. Sci. 39 (1998) 1789-96.
  Organism
Homo sapiens
  Sequence
[hsa:1515]
Reference
3  [PMID:9563472]
  Authors
Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C.
  Title
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
  Journal
Cancer. Res. 58 (1998) 1624-30.
  Organism
Homo sapiens
  Sequence
[hsa:1515]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
223670-00-6

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