KEGG   ENZYME: 3.4.22.45Help
Entry
EC 3.4.22.45                Enzyme                                 

Name
helper-component proteinase;
HC-Pro
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolyses a Gly!Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly!Gly, in the processing of the potyviral polyprotein
Comment
Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6.
History
EC 3.4.22.45 created 2001
Reference
1  [PMID:7747479]
  Authors
Kasschau KD, Carrington JC.
  Title
Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus.
  Journal
Virology. 209 (1995) 268-73.
  Organism
tobacco etch potyvirus
Reference
2
  Authors
Verchot, J.
  Title
Potyvirus helper component proteinase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 677-679.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
124566-20-7

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