KEGG   ENZYME: 3.4.22.47Help
Entry
EC 3.4.22.47                Enzyme                                 

Name
gingipain K;
Lys-gingipain;
PrtP proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase with strict specificity for lysyl bonds
Comment
Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.
History
EC 3.4.22.47 created 2003
Reference
1  [PMID:8276827]
  Authors
Pike R, McGraw W, Potempa J, Travis J.
  Title
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.
  Journal
J. Biol. Chem. 269 (1994) 406-11.
  Organism
Porphyromonas gingivalis
Reference
2  [PMID:12438376]
  Authors
Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B.
  Title
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor.
  Journal
Infect. Immun. 70 (2002) 6968-75.
  Organism
Porphyromonas gingivalis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
159745-69-4

DBGET integrated database retrieval system