KEGG   ENZYME: 3.4.22.52Help
Entry
EC 3.4.22.52                Enzyme                                 
Name
calpain-1;
mu-calpain;
calcium-activated neutral protease I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2.
Orthology
K01367  
calpain-1
Genes
HSA: 
823(CAPN1)
PTR: 
451317(CAPN1)
PPS: 
100975624(CAPN1)
GGO: 
101139860(CAPN1)
PON: 
100174090(CAPN1)
MCC: 
716618(CAPN1)
MMU: 
12333(Capn1)
RNO: 
29153(Capn1)
CFA: 
483745(CAPN1)
AML: 
FCA: 
101096916(CAPN1)
BTA: 
281661(CAPN1)
SSC: 
397027(CAPN1)
ECB: 
100051106
MDO: 
100030405
SHR: 
100927376(CAPN1)
GGA: 
396240(CAPN1) 693249(CAPN1)
MGP: 
100549763
ACS: 
100560015(capn1) 100567116
XLA: 
380177(capn1) 398288 398772 447208
XTR: 
541454(capn1) 541455(capn1)
DRE: 
393417(capn1a) 406768(Capn1) 553353(capn1)
TRU: 
101063922 101075956
OLA: 
101163842
 » show all
Taxonomy
Reference
1  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem. J. 367 (2002) 263-9.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
78990-62-2
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