KEGG   ENZYME: 3.4.22.53Help
Entry
EC 3.4.22.53                Enzyme                                 
Name
calpain-2;
calcium-activated neutral protease II;
m-calpain;
milli-calpain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.
Orthology
K03853  
calpain-2
Genes
HSA: 
824(CAPN2)
PTR: 
457765(CAPN2)
PPS: 
100988890(CAPN2)
GGO: 
101149206(CAPN2)
PON: 
100445754(CAPN2)
MCC: 
703047(CAPN2)
MMU: 
12334(Capn2)
RNO: 
29154(Capn2)
CFA: 
480118(CAPN2)
AML: 
FCA: 
101083231(CAPN2)
BTA: 
281662(CAPN2)
SSC: 
397393(CAPN2)
ECB: 
100055184(CAPN2)
MDO: 
100018672
OAA: 
100081577(CAPN2)
GGA: 
395963(CAPN2)
MGP: 
100546180
TGU: 
100229579(CAPN2)
ACS: 
100561808
XLA: 
399075(capn2)
XTR: 
448035(capn2.2)
DRE: 
541374(capn2a) 550505(capn2l)
TRU: 
101076595
 » show all
Taxonomy
Reference
1  [PMID:10639123]
  Authors
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.
  Title
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 588-92.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem. J. 367 (2002) 263-9.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
702693-80-9
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