KEGG   ENZYME: 3.4.22.63Help
Entry
EC 3.4.22.63                Enzyme                                 

Name
caspase-10;
FLICE2, Mch4;
CASP-10;
ICE-like apoptotic protease 4;
apoptotic protease Mch-4;
FAS-associated death domain protein interleukin-1beta-converting enzyme 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Comment
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.
History
EC 3.4.22.63 created 2007
Orthology
K04400  
caspase 10
Genes
HSA: 
843(CASP10)
PTR: 
459873(CASP10)
PPS: 
100972863(CASP10)
GGO: 
101131419(CASP10)
PON: 
100174433(CASP10)
MCC: 
701295(CASP10)
MCF: 
102144792(CASP10)
HGL: 
101712620(Casp10)
TUP: 
102496563(CASP10)
CFA: 
488472(CASP10)
AML: 
FCA: 
101085995(CASP10)
PTG: 
102962753(CASP10)
SSC: 
100154896(CASP10)
CFR: 
102514092(CASP10)
ECB: 
100068201(CASP10)
MYB: 
MYD: 
102763065(CASP10)
PALE: 
102877929(CASP10)
MDO: 
SHR: 
100930260(CASP10)
OAA: 
GGA: 
424081(CASP10)
MGP: 
TGU: 
100220453(CASP10)
FAB: 
101815409(CASP10)
PHI: 
102103849(CASP10)
APLA: 
101799731(CASP10)
FPG: 
101918719(CASP10)
FCH: 
102057122(CASP10)
CLV: 
102085114(CASP10)
ASN: 
102380890(CASP10)
PSS: 
CMY: 
102931579(CASP10)
ACS: 
XLA: 
397820(casp10) 398762(MGC68465)
XTR: 
548432(casp10)
TRU: 
LCM: 
 » show all
Taxonomy
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol. Mol. Biol. Rev. 64 (2000) 821-46.
Reference
2  [PMID:16186808]
  Authors
Fischer U, Stroh C, Schulze-Osthoff K.
  Title
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
  Journal
Oncogene. 25 (2006) 152-9.
Reference
3  [PMID:12884866]
  Authors
Shikama Y, Yamada M, Miyashita T.
  Title
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
  Journal
Eur. J. Immunol. 33 (2003) 1998-2006.
Reference
4  [PMID:15209560]
  Authors
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
  Title
Activation of caspases-8 and -10 by FLIP(L).
  Journal
Biochem. J. 382 (2004) 651-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
189088-85-5

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