caspase-10;
FLICE2, Mch4;
CASP-10;
ICE-like apoptotic protease 4;
apoptotic protease Mch-4;
FAS-associated death domain protein interleukin-1beta-converting enzyme 2

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly

Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.

1  [PMID:11104820]

Chang HY, Yang X.

Proteases for cell suicide: functions and regulation of caspases.

Microbiol. Mol. Biol. Rev. 64 (2000) 821-46.

2  [PMID:16186808]

Fischer U, Stroh C, Schulze-Osthoff K.

Unique and overlapping substrate specificities of caspase-8 and caspase-10.

Oncogene. 25 (2006) 152-9.

3  [PMID:12884866]

Shikama Y, Yamada M, Miyashita T.

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.

Eur. J. Immunol. 33 (2003) 1998-2006.

4  [PMID:15209560]

Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.

Activation of caspases-8 and -10 by FLIP(L).

Biochem. J. 382 (2004) 651-7.