KEGG   ENZYME: 3.4.22.64Help
Entry
EC 3.4.22.64                Enzyme                                 

Name
caspase-11;
CASP-11
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp!
Comment
This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.
History
EC 3.4.22.64 created 2007
Orthology
K12808  
caspase 11
Genes
MMU: 
12363(Casp4)
Taxonomy
Reference
1  [PMID:10791975]
  Authors
Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA, Yuan J.
  Title
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
  Journal
J. Cell. Biol. 149 (2000) 613-22.
Reference
2  [PMID:11684090]
  Authors
Hur J, Kim SY, Kim H, Cha S, Lee MS, Suk K.
  Title
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway.
  Journal
FEBS. Lett. 507 (2001) 157-62.
Reference
3  [PMID:9491891]
  Authors
Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J.
  Title
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
  Journal
Cell. 92 (1998) 501-9.
Reference
4  [PMID:16670335]
  Authors
Endo M, Mori M, Akira S, Gotoh T.
  Title
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.
  Journal
J. Immunol. 176 (2006) 6245-53.
  Sequence
[mmu:12363]
Reference
5  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol. Mol. Biol. Rev. 64 (2000) 821-46.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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