KEGG   ENZYME: 3.4.22.8Help
Entry
EC 3.4.22.8                 Enzyme                                 

Name
clostripain;
clostridiopeptidase B;
clostridium histolyticum proteinase B;
alpha-clostridipain;
clostridiopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, including Arg!Pro, but not Lys-
Comment
From the bacterium Clostridium histolyticum. It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family C11.
History
EC 3.4.22.8 created 1961 as EC 3.4.4.20, transferred 1972 to EC 3.4.22.8
Orthology
K08587  
clostripain
Genes
CPE: 
CPF: 
CPF_0840(cloSI)
CPR: 
CPR_0833(cloSI)
CNO: 
CBO: 
CBO1920(closI)
CBA: 
CLB_1857(cloSI)
CBH: 
CLC_1864(cloSI)
CBY: 
CLM_2137(cloSI)
CBL: 
CLK_1375(cloSI)
CBB: 
CLD_2707(cloSI)
CBI: 
CLJ_B2122(cloSI)
CBN: 
CBF: 
CLI_1984(cloSI)
 » show all
Taxonomy
Reference
1  [PMID:927173]
  Authors
Mitchell WM.
  Title
Cleavage at arginine residues by clostripain.
  Journal
Methods. Enzymol. 47 (1977) 165-70.
Reference
2  [PMID:762145]
  Authors
Gilles AM, Imhoff JM, Keil B.
  Title
alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain.
  Journal
J. Biol. Chem. 254 (1979) 1462-8.
Reference
3  [PMID:6391922]
  Authors
Gilles AM, Lecroisey A, Keil B.
  Title
Primary structure of alpha-clostripain light chain.
  Journal
Eur. J. Biochem. 145 (1984) 469-76.
  Sequence
[up:P09870]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-00-6

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