KEGG   ENZYME: 3.4.23.24Help
Entry
EC 3.4.23.24                Enzyme                                 

Name
candidapepsin;
Candida albicans aspartic proteinase;
Candida albicans carboxyl proteinase;
Candida albicans secretory acid proteinase;
Candida olea acid proteinase;
Candida aspartic proteinase;
Candida olea aspartic proteinase;
Candida albicans aspartic proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
Comment
This endopeptidase from the imperfect yeast Candida albicans is inhibited by pepstatin, but not by methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6
History
EC 3.4.23.24 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K06005  
candidapepsin
Genes
CAL: 
CaO19.11193(SAP2) CaO19.11320(SAP10) CaO19.12988(SAP6) CaO19.13032(SAP5) CaO19.13137(SAP1) CaO19.13139(SAP4) CaO19.13422(SAP3) CaO19.14190(SAP9) CaO19.242(SAP8) CaO19.3708(SAP2) CaO19.3839(SAP10) CaO19.5542(SAP6) CaO19.5585(SAP5) CaO19.5714(SAP1) CaO19.5716(SAP4) CaO19.6001(SAP3) CaO19.6928(SAP9) CaO19.756(SAP7) CaO19.7872(SAP8) CaO19.8376(SAP7)
CTP: 
COT: 
CDU: 
CD36_04610(SAP7) CD36_33460(SAP2) CD36_44180(SAP10) CD36_63420(SAP6) CD36_63430(SAP1) CD36_82480(SAP8) CD36_83850(SAP9) CD36_85220(SAP3)
CTEN: 
Taxonomy
Reference
1  [PMID:5729955]
  Authors
Remold H, Fasold H, Staib F.
  Title
Purification and characterization of a proteolytic enzyme from Candida albicans.
  Journal
Biochim. Biophys. Acta. 167 (1968) 399-406.
  Organism
Candida albicans
Reference
2  [PMID:7018586]
  Authors
Ruchel R.
  Title
Properties of a purified proteinase from the yeast Candida albicans.
  Journal
Biochim. Biophys. Acta. 659 (1981) 99-113.
  Organism
Candida albicans
Reference
3  [PMID:6203988]
  Authors
Negi M, Tsuboi R, Matsui T, Ogawa H.
  Title
Isolation and characterization of proteinase from Candida albicans: substrate specificity.
  Journal
J. Invest. Dermatol. 83 (1984) 32-6.
  Organism
Candida albicans
Reference
4  [PMID:2646602]
  Authors
Lott TJ, Page LS, Boiron P, Benson J, Reiss E.
  Title
Nucleotide sequence of the Candida albicans aspartyl proteinase gene.
  Journal
Nucleic. Acids. Res. 17 (1989) 1779.
  Organism
Candida albicans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69458-91-9

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