KEGG   ENZYME: 3.4.23.3Help
Entry
EC 3.4.23.3                 Enzyme                                 

Name
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
Comment
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
Orthology
K01377  
gastricsin
Genes
HSA: 
5225(PGC)
PTR: 
462684(PGC)
PPS: 
GGO: 
PON: 
MCF: 
MMU: 
109820(Pgc)
RNO: 
24864(Pgc)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
FCA: 
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
102255177(PGC) 102261843(Gastricsin)
MYD: 
102755151(PGC) 102772869(Gastricsin)
PALE: 
MDO: 
SHR: 
GGA: 
MGP: 
FAB: 
PHI: 
APLA: 
FPG: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
373563(pgc-A)
XTR: 
LCM: 
 » show all
Taxonomy
Reference
1
  Authors
Ryle, A.P.
  Title
The porcine pepsins and pepsinogens.
  Journal
Methods Enzymol. 19 (1970) 316-336.
Reference
2
  Authors
Tang, J.
  Title
Gastricsin and pepsin.
  Journal
Methods Enzymol. 19 (1970) 406-421.
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays. Biochem. 17 (1981) 52-84.
Reference
4  [PMID:6816595]
  Authors
Foltmann B, Jensen AL.
  Title
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.
  Journal
Eur. J. Biochem. 128 (1982) 63-70.
  Organism
Homo sapiens
  Sequence
[hsa:5225]
Reference
5  [PMID:6800788]
  Authors
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.
  Title
Purification and characterization of bovine gastricsin.
  Journal
Eur. J. Biochem. 122 (1982) 31-9.
  Organism
Bos taurus
Reference
6  [PMID:6432332]
  Authors
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.
  Title
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
  Journal
Cell. Tissue. Res. 236 (1984) 597-600.
  Organism
Homo sapiens
Reference
7  [PMID:3335549]
  Authors
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.
  Title
Primary structure of human pepsinogen C gene.
  Journal
J. Biol. Chem. 263 (1988) 1382-5.
  Organism
Homo sapiens
  Sequence
[hsa:5225]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-71-9

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