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Entry
EC 3.4.23.45                Enzyme                                 

Name
memapsin 1;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2);
ASP1;
Down region aspartic protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.
History
EC 3.4.23.45 created 2003
Orthology
K07747  
beta-site APP-cleaving enzyme 2 (memapsin 1)
Genes
HSA: 
25825(BACE2)
PTR: 
747819(BACE2)
PPS: 
100990201(BACE2)
GGO: 
101131488(BACE2)
PON: 
100442149(BACE2)
NLE: 
100598433(BACE2)
MCC: 
715330(BACE2)
MCF: 
102140609(BACE2)
CJC: 
100406072(BACE2)
MMU: 
56175(Bace2)
RNO: 
288227(Bace2)
CGE: 
100764950(Bace2)
NGI: 
103748454(Bace2)
HGL: 
101717943(Bace2)
OCU: 
100342092(BACE2)
TUP: 
102498668(BACE2)
CFA: 
478418(BACE2)
UMR: 
103680727(BACE2)
FCA: 
101096756(BACE2)
PTG: 
102955826(BACE2)
BTA: 
534774(BACE2)
BOM: 
102272554(BACE2)
PHD: 
102317728(BACE2)
CHX: 
102187812(BACE2)
OAS: 
101102027(BACE2)
SSC: 
100517374(BACE2)
CFR: 
102516803(BACE2)
BACU: 
103014984(BACE2)
LVE: 
103085141(BACE2)
ECB: 
100058700(BACE2)
MYB: 
102254769(BACE2)
MYD: 
102767911(BACE2)
PALE: 
102896199(BACE2)
MDO: 
100016587(BACE2)
SHR: 
100932104(BACE2)
OAA: 
100080196(BACE2)
GGA: 
418526(BACE2)
MGP: 
100547969(BACE2)
APLA: 
101795939(BACE2)
TGU: 
100224177(BACE2)
FAB: 
101816221(BACE2)
PHI: 
102107969(BACE2)
FPG: 
101919630(BACE2)
FCH: 
102051138(BACE2)
CLV: 
102088959(BACE2)
ASN: 
102386120(BACE2)
AMJ: 
102561959(BACE2)
PSS: 
102447109(BACE2)
CMY: 
102940897(BACE2)
ACS: 
100552914(bace2)
PBI: 
103059516(BACE2)
XLA: 
380307(bace2) 398806(bace2)
XTR: 
100216145(bace2)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362842(BACE2)
CMK: 
103187270(bace2)
ISC: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:12093293]
  Authors
Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J.
  Title
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
  Journal
Biochemistry. 41 (2002) 8742-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
447457-31-0

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