KEGG   ENZYME: 3.4.23.5Help
Entry
EC 3.4.23.5                 Enzyme                                 
Name
cathepsin D
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin
Comment
Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family).
Orthology
K01379  
cathepsin D
Genes
HSA: 
1509(CTSD)
PTR: 
746637(CTSD)
PPS: 
100974319(CTSD)
GGO: 
101125251(CTSD)
PON: 
100172401(CTSD)
MCC: 
703534(CTSD)
MMU: 
13033(Ctsd)
RNO: 
171293(Ctsd)
CFA: 
483662(CTSD)
AML: 
FCA: 
101094625(CTSD)
BTA: 
282883(CTSD)
SSC: 
494568(CTSD)
SHR: 
100917285
OAA: 
100090301
GGA: 
396090(CTSD)
MGP: 
100543618
TGU: 
100232592(CTSD)
ACS: 
100567238
XLA: 
398557 398994(napsa) 443721(ctsd) 443829
XTR: 
394561(ctsd) 448214(napsa) 493534 613063
DRE: 
336746(fa94d12) 65225(ctsd)
TRU: 
777955(ctsd1)
OLA: 
101161712 101168958
BFO: 
BRAFLDRAFT_74093
CIN: 
100176563
SPU: 
575021
DME: 
Dmel_CG10104 Dmel_CG1548(cathD) Dmel_CG5863 Dmel_CG6508
DPO: 
Dpse_GA13759
DAN: 
Dana_GF11236 Dana_GF13504 Dana_GF16402 Dana_GF19727
DER: 
Dere_GG10707 Dere_GG20455 Dere_GG22202 Dere_GG23677
DPE: 
Dper_GL10692 Dper_GL11239 Dper_GL23572
DSE: 
Dsec_GM15229 Dsec_GM18741 Dsec_GM20753 Dsec_GM21542
DSI: 
Dsim_GD10217 Dsim_GD11051 Dsim_GD19155 Dsim_GD23735
DWI: 
Dwil_GK11645 Dwil_GK21477 Dwil_GK21682
DYA: 
Dyak_GE10129 Dyak_GE13586 Dyak_GE18490 Dyak_GE23596
DGR: 
Dgri_GH19747 Dgri_GH21578
DMO: 
Dmoj_GI19550 Dmoj_GI20282
DVI: 
Dvir_GJ21122 Dvir_GJ22010
AGA: 
AgaP_AGAP003277
AAG: 
AaeL_AAEL006169
CQU: 
CpipJ_CPIJ017185
AME: 
409341(cathD)
NVI: 
100114169(NV17251)
TCA: 
655494
API: 
100168373(Cathd)
PHU: 
Phum_PHUM318500
ISC: 
IscW_ISCW023880
CEL: 
CELE_R12H7.2(asp-4)
CBR: 
CBG05258(Cbr-asp-4)
BMY: 
Bm1_12055
TSP: 
Tsp_06028
SMM: 
Smp_013040.1 Smp_013040.2
NVE: 
NEMVE_v1g81470
HMG: 
100203582
TAD: 
TRIADDRAFT_36909
AQU: 
100634519 100636908
ATH: 
AT1G69100 AT4G22050
ALY: 
ARALYDRAFT_894690
CRE: 
CHLREDRAFT_128744(ASP1)
CME: 
CMN194C
AFM: 
AFUA_4G07040
PPL: 
POSPLDRAFT_100521
MPR: 
MPER_10342
CCI: 
CC1G_03281
SCM: 
SCHCODRAFT_65201
NGR: 
NAEGRDRAFT_32195 NAEGRDRAFT_81926
DDI: 
DDB_G0279411(ctsD)
DPP: 
DICPUDRAFT_47729
PVX: 
PVX_086040
PCY: 
PCYB_134860
TET: 
TTHERM_00052190 TTHERM_00128320 TTHERM_00321680
TPS: 
THAPSDRAFT_36297
 » show all
Taxonomy
Reference
1
  Authors
Barrett, A.J.
  Title
Cathepsin D and other carboxyl proteinases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 209-248.
Reference
2  [PMID:7341918]
  Authors
Takahashi T, Tang J.
  Title
Cathepsin D from porcine and bovine spleen.
  Journal
Methods. Enzymol. 80 Pt C (1981) 565-81.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:3927292]
  Authors
Faust PL, Kornfeld S, Chirgwin JM.
  Title
Cloning and sequence analysis of cDNA for human cathepsin D.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 4910-4.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:2512908]
  Authors
Conner GE.
  Title
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme.
  Journal
Biochem. J. 263 (1989) 601-4.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-26-7
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