KEGG   ENZYME: 3.4.23.5Help
Entry
EC 3.4.23.5                 Enzyme                                 

Name
cathepsin D
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin
Comment
Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.5 created 1965 as EC 3.4.4.23, transferred 1972 to EC 3.4.23.5, modified 1986
Orthology
K01379  
cathepsin D
Genes
HSA: 
1509(CTSD)
PTR: 
746637(CTSD)
PPS: 
100974319(CTSD)
GGO: 
101125251(CTSD)
PON: 
100172401(CTSD)
MCC: 
703534(CTSD)
MCF: 
102125635(CTSD)
MMU: 
13033(Ctsd)
RNO: 
171293(Ctsd)
CGE: 
100766628(Ctsd)
HGL: 
101716979(Ctsd)
TUP: 
102474582(CTSD)
CFA: 
483662(CTSD)
AML: 
FCA: 
101094625(CTSD)
BTA: 
282883(CTSD)
BOM: 
102275829(CTSD)
PHD: 
102343491(CTSD)
SSC: 
494568(CTSD)
CFR: 
MYB: 
102255890(CTSD)
SHR: 
OAA: 
GGA: 
396090(CTSD)
MGP: 
TGU: 
100232592(CTSD)
FAB: 
101814740(CTSD)
PHI: 
102113116(CTSD)
APLA: 
101792449(CTSD)
FPG: 
101917516(CTSD)
FCH: 
102054100(CTSD)
CLV: 
102090198(CTSD)
ASN: 
PSS: 
102448444(CTSD)
ACS: 
XLA: 
398557 398994(napsa) 443721(ctsd) 443829
XTR: 
394561(ctsd) 448214(napsa) 493534 613063
DRE: 
336746(fa94d12) 65225(ctsd)
TRU: 
777955(ctsd1)
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409341(cathD)
NVI: 
TCA: 
BMOR: 
692768(CatD)
API: 
100168373(Cathd)
PHU: 
ISC: 
CEL: 
CBR: 
CBG05258(Cbr-asp-4)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
CME: 
AFM: 
PPL: 
MPR: 
CCI: 
SCM: 
DDI: 
DPP: 
DFA: 
DFA_06766(ctsD)
PVX: 
PCY: 
TET: 
TPS: 
NGD: 
EHX: 
NGR: 
 » show all
Taxonomy
Reference
1
  Authors
Barrett, A.J.
  Title
Cathepsin D and other carboxyl proteinases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 209-248.
Reference
2  [PMID:7341918]
  Authors
Takahashi T, Tang J.
  Title
Cathepsin D from porcine and bovine spleen.
  Journal
Methods. Enzymol. 80 Pt C (1981) 565-81.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:3927292]
  Authors
Faust PL, Kornfeld S, Chirgwin JM.
  Title
Cloning and sequence analysis of cDNA for human cathepsin D.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 4910-4.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:1509]
Reference
4  [PMID:2512908]
  Authors
Conner GE.
  Title
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme.
  Journal
Biochem. J. 263 (1989) 601-4.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-26-7

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