| Entry |
|
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| Name |
atrolysin A;
Crotalus atrox metalloendopeptidase a;
hemorrhagic toxin a;
Crotalus atrox alpha-proteinase;
Crotalus atrox proteinase;
bothropasin
|
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
 |
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| Reaction(IUBMB) |
Cleavage of Asn3!Gln, His5!Leu, His10!Leu, Ala14!Leu and Tyr16!Leu in insulin B chain; removes C-terminal Leu from small peptides
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| Comment |
A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity [2]. In peptidase family M12 (astacin family). Related metalloendopeptidases from rattlesnake venoms are EC 3.4.24.41 (atrolysin B), EC 3.4.24.42 (atrolysin C), EC 3.4.24.43 (atroxase), EC 3.4.24.44 (atrolysin E), EC 3.4.24.45 (atrolysin F), EC 3.4.24.46 (adamalysin), EC 3.4.24.47 (horrilysin), and EC 3.4.24.48 (ruberlysin)
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| Reference |
|
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| Authors |
Bjarnason JB, Tu AT. |
|---|
| Title |
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. |
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| Journal |
Biochemistry. 17 (1978) 3395-404. |
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| Organism |
Crotalus atrox |
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| Reference |
|
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| Authors |
Mori N, Nikai T, Sugihara H, Tu AT. |
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| Title |
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom. |
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| Journal |
Arch. Biochem. Biophys. 253 (1987) 108-21. |
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| Organism |
Crotalus ruber ruber |
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| Reference |
|
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| Authors |
Bjarnason JB, Hamilton D, Fox JW. |
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| Title |
Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom. |
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| Journal |
Biol. Chem. Hoppe. Seyler. 369 Suppl (1988) 121-9. |
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| Organism |
Crotalus atrox |
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| Reference |
4 |
|---|
| Authors |
Bjarnason, J.B. and Fox, J.W. |
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| Title |
Hemorrhagic toxins from snake venoms. |
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| Journal |
J. Toxicol. Toxin Rev. 7 (1989) 121-209. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37288-82-7 |
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