KEGG   ENZYME: 3.4.24.11Help
Entry
EC 3.4.24.11                Enzyme                                 
Name
neprilysin;
neutral endopeptidase;
endopeptidase 24.11;
kidney-brush-border neutral peptidase;
enkephalinase (misleading);
endopeptidase-2;
CALLA (common acute lymphoblastic leukemia-associated) antigens;
CALLA antigen;
endopeptidase;
membrane metalloendopeptidase;
kidney-brush-border neutral endopeptidase;
kidney-brush-border neutral proteinase;
endopeptidase-2;
CALLA glycoprotein;
CALLA;
common acute lymphoblastic leukemia antigen;
CALLA glycoproteins;
common acute lymphoblastic leukemia-associated antigens;
neutral metallendopeptidase;
membrane metalloendopeptidase;
NEP;
neutral endopeptidase 24.11;
CD10;
neutral endopeptidase;
acute lymphoblastic leukemia antigen
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Comment
A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13
Orthology
K01389  
neprilysin
Genes
HSA: 
4311(MME)
PTR: 
460792(MME)
PPS: 
GGO: 
PON: 
MCC: 
707667(MME)
MMU: 
17380(Mme)
RNO: 
24590(Mme)
CFA: 
477120(MME)
AML: 
FCA: 
101087516(MME)
BTA: 
536741(MME)
SSC: 
100511536(MME)
ECB: 
100053541(MME)
MDO: 
100012497
SHR: 
100920293(MME)
OAA: 
100075251 100092983
GGA: 
425031(MME)
MGP: 
100544190
TGU: 
100224600(MME)
ACS: 
100558527
OLA: 
101170860
BFO: 
BRAFLDRAFT_278852
CEL: 
CELE_F26G1.6(nep-12)
MVA: 
Mvan_0184
MGI: 
Mflv_0472
MMC: 
Mmcs_0157
MKM: 
Mkms_0166
MJL: 
Mjls_0147
RHA: 
RHA1_ro05118
 » show all
Taxonomy
Reference
1  [PMID:6190172]
  Authors
Matsas R, Fulcher IS, Kenny AJ, Turner AJ.
  Title
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 3111-5.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:3555489]
  Authors
Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ.
  Title
Molecular cloning and amino acid sequence of rat enkephalinase.
  Journal
Biochem. Biophys. Res. Commun. 144 (1987) 59-66.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:2971756]
  Authors
Letarte M, Vera S, Tran R, Addis JB, Onizuka RJ, Quackenbush EJ, Jongeneel CV, McInnes RR.
  Title
Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
  Journal
J. Exp. Med. 168 (1988) 1247-53.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:2521610]
  Authors
Erdos EG, Skidgel RA.
  Title
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones.
  Journal
FASEB. J. 3 (1989) 145-51.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno], Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82707-54-8
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