KEGG   ENZYME: 3.4.24.14Help
Entry
EC 3.4.24.14                Enzyme                                 
Name
procollagen N-endopeptidase;
procollagen N-terminal peptidase;
procollagen aminopeptidase;
aminoprocollagen peptidase;
aminoterminal procollagen peptidase;
procollagen aminoterminal protease;
procollagen N-terminal proteinase;
type I/II procollagen N-proteinase;
type III procollagen
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro!Gln and of alpha1(II) and alpha2(I) at Ala!Gln
Comment
Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family)
Orthology
K08618  
a disintegrin and metalloproteinase with thrombospondin motifs 2
Genes
HSA: 
9509(ADAMTS2)
PTR: 
462325(ADAMTS2)
PPS: 
100979430(ADAMTS2)
GGO: 
101142866(ADAMTS2)
PON: 
100447800(ADAMTS2)
MCC: 
713532(ADAMTS2)
MMU: 
216725(Adamts2)
RNO: 
287899(Adamts2)
CFA: 
481453(ADAMTS2)
AML: 
FCA: 
101096945(ADAMTS2)
BTA: 
282401(ADAMTS2)
SSC: 
100521434
MDO: 
100029340(ADAMTS2)
SHR: 
100920081(ADAMTS2)
OAA: 
100074059
GGA: 
416291(ADAMTS2)
MGP: 
100538388
TGU: 
100224296(ADAMTS2)
ACS: 
100557740
XTR: 
100492431
DRE: 
571682(adamts3)
TRU: 
101063894
OLA: 
101157225
 » show all
Taxonomy
Reference
1  [PMID:4204204]
  Authors
Kohn LD, Isersky C, Zupnik J, Lenaers A, Lee G, Lapiere CM.
  Title
Calf tendon procollagen peptidase: its purification and endopeptidase mode of action.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 71 (1974) 40-4.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:2500439]
  Authors
Hojima Y, McKenzie JA, van der Rest M, Prockop DJ.
  Title
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.
  Journal
J. Biol. Chem. 264 (1989) 11336-45.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
68651-94-5
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