| Entry |
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| Name |
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
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| Comment |
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | GGA: | | MGP: | | TGU: | | XLA: | | XTR: | | DRE: | | TRU: | | BFO: | | CIN: | | SMM: | | NVE: | | HMG: | | TAD: | | OSA: | | OLU: | | OTA: | | CME: | | MBR: | | DDI: | | TBR: | | TCR: | | LMA: | | LIF: | | LBZ: | | CJA: | | ABC: | | ABN: | | SDE: | | MPT: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | SUR: | | SCL: | | HOH: | | OIH: | | MTS: | | ICA: | | NCA: | | ACA: | | TSA: | | SUS: | | EMI: | |
» show all
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| Reference |
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| Authors |
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC. |
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| Title |
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides. |
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| Journal |
Peptides. 9 (1988) 945-55. |
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| Organism |
Oryctolagus cuniculus |
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| Reference |
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| Authors |
Orlowski M, Reznik S, Ayala J, Pierotti AR. |
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| Title |
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides. |
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| Journal |
Biochem. J. 261 (1989) 951-8. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Barrett AJ, Brown MA. |
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| Title |
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase. |
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| Journal |
Biochem. J. 271 (1990) 701-6. |
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| Organism |
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| Reference |
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| Authors |
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL. |
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| Title |
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15. |
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| Journal |
Biochemistry. 29 (1990) 10323-9. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Tisljar U, Barrett AJ. |
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| Title |
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit. |
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| Journal |
Biochem. J. 267 (1990) 531-3. |
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| Organism |
Rattus norvegicus [GN: rno], Oryctolagus cuniculus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 110639-28-6 |
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