KEGG   ENZYME: 3.4.24.15Help
Entry
EC 3.4.24.15                Enzyme                                 

Name
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Comment
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
Orthology
K01392  
thimet oligopeptidase
Genes
HSA: 
7064(THOP1)
PTR: 
750162(THOP1)
PPS: 
100985112(THOP1)
GGO: 
101143234(THOP1)
PON: 
100455971(THOP1)
MCC: 
721578(THOP1)
MCF: 
102117812(THOP1)
MMU: 
50492(Thop1)
RNO: 
64517(Thop1)
CGE: 
HGL: 
101714143(Thop1)
TUP: 
102500342(THOP1)
CFA: 
476748(THOP1)
AML: 
FCA: 
101083746(THOP1)
BTA: 
510889(THOP1)
BOM: 
102265369(THOP1)
PHD: 
CHX: 
102178165(THOP1)
SSC: 
397442(THOP1)
CFR: 
102508107(THOP1)
ECB: 
100059667(THOP1)
MYB: 
102262534(THOP1)
MDO: 
100020499(THOP1)
SHR: 
100924623(THOP1)
GGA: 
MGP: 
TGU: 
100231983(THOP1)
FAB: 
101805763(THOP1)
PHI: 
102110662(THOP1)
APLA: 
101804753(THOP1)
FPG: 
101913462(THOP1)
FCH: 
102053721(THOP1)
CLV: 
102095097(THOP1)
ASN: 
102383675(THOP1)
PSS: 
102457370(THOP1)
XLA: 
397806(thop1)
XTR: 
779863(thop1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357708(THOP1)
BFO: 
CIN: 
ISC: 
SMM: 
NVE: 
HMG: 
TAD: 
CRB: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0010s06460g(POPTRDRAFT_565929)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0902200-01(Os01g0902200)
BDI: 
SBI: 
SORBI_03g042960(SORBIDRAFT_03g042960)
ZMA: 
100280152(si683006e11)
SITA: 
SMO: 
PPP: 
OLU: 
OTA: 
CME: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PIF: 
GTT: 
TBR: 
Tb927.7.190(Tb07.8P12.250)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
CJA: 
ABC: 
ABN: 
SDE: 
MPT: 
CFU: 
ADE: 
ACP: 
AFW: 
ANK: 
MXA: 
MFU: 
MSD: 
CCX: 
SUR: 
SCL: 
sce4462(prlC1)
SCU: 
HOH: 
DPB: 
BABL1_25(prlC)
OIH: 
NBR: 
MTS: 
CFI: 
CGA: 
ICA: 
NCA: 
ACA: 
GMA: 
TSA: 
SUS: 
EMI: 
FLI: 
 » show all
Taxonomy
Reference
1  [PMID:3244563]
  Authors
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
  Title
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
  Journal
Peptides. 9 (1988) 945-55.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:2803255]
  Authors
Orlowski M, Reznik S, Ayala J, Pierotti AR.
  Title
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
  Journal
Biochem. J. 261 (1989) 951-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:2123097]
  Authors
Barrett AJ, Brown MA.
  Title
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
  Journal
Biochem. J. 271 (1990) 701-6.
  Organism
Gallus gallus [GN:gga]
Reference
4  [PMID:2261476]
  Authors
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.
  Title
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.
  Journal
Biochemistry. 29 (1990) 10323-9.
  Organism
Rattus norvegicus [GN:rno]
  Sequence
[rno:64517]
Reference
5  [PMID:2185743]
  Authors
Tisljar U, Barrett AJ.
  Title
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
  Journal
Biochem. J. 267 (1990) 531-3.
  Organism
Rattus norvegicus [GN:rno], Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110639-28-6

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