KEGG   ENZYME: 3.4.24.16Help
Entry
EC 3.4.24.16                Enzyme                                 
Name
neurolysin;
neurotensin endopeptidase;
endopeptidase 24.16;
endo-oligopeptidase B (proline-endopeptidase)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage in neurotensin: Pro10!Tyr
Comment
No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)
Orthology
K01393  
neurolysin
Genes
HSA: 
57486(NLN)
PTR: 
461840(NLN)
PPS: 
GGO: 
PON: 
MCC: 
MMU: 
75805(Nln)
RNO: 
117041(Nln)
CFA: 
478081(NLN)
AML: 
BTA: 
538650(NLN)
SSC: 
100517788 397646(NLN)
ECB: 
100057244(NLN)
MDO: 
100032431
SHR: 
100923397(NLN)
OAA: 
100090269
GGA: 
427167(NLN)
TGU: 
100226752(NLN)
ACS: 
100562733
XTR: 
100158603(nln)
SPU: 
594682
 » show all
Taxonomy
Reference
1  [PMID:3525564]
  Authors
Checler F, Vincent JP, Kitabgi P.
  Title
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.
  Journal
J. Biol. Chem. 261 (1986) 11274-81.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:3409880]
  Authors
Barelli H, Vincent JP, Checler F.
  Title
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum.
  Journal
Eur. J. Biochem. 175 (1988) 481-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:2649078]
  Authors
Checler F, Barelli H, Vincent JP.
  Title
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies.
  Journal
Biochem. J. 257 (1989) 549-54.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149371-24-4
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